Sp 5,6-DCl-cBIMPS

• 产品号: S6069
• CAS号: 120912-54-1
• 分子式: C12H10Cl2N2NaO5PS
• 分子量: 419.152731
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Sp 5,6-DCl-cBIMPS
• IUPAC标准名: sodium [(2S,4aR,6R,7R,7aS)-6-(5,6-dichloro-1H-1,3-benzodiazol-1-yl)-7-hydroxy-2-oxo-hexahydro-1,3,5,2λ^5-furo[3,2-d][1,3,2λ^5]dioxaphosphinin-2-yl]sulfanide
• IUPAC传统名: sodium [(2S,4aR,6R,7R,7aS)-6-(5,6-dichloro-1,3-benzodiazol-1-yl)-7-hydroxy-2-oxo-tetrahydro-4H-1,3,5,2λ^5-furo[3,2-d][1,3,2λ^5]dioxaphosphinin-2-yl]sulfanide
• 别名: 5,6-Dichloro-1-b-D-ribofuranosylbenzimidazole-3′,5′-cyclic monophosphorothioate, Sp- isomer sodium salt

产品登记号

• MDL号: MFCD06795834
• CAS号: 120912-54-1
• PubChem SID: 24724615

产品性质

• Empirical Formula (Hill Notation): C12H10Cl2N2O5PSNa
• 纯度: ≥98% (HPLC)
• 运输包装: dry ice
• 外观: white solid
• 溶解度: H2O: soluble1 mM
• 溶解度: DMSO: freely soluble
• 溶解度: ethanol: freely soluble
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: -70°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Selective cAMP-dependent protein kinase (PKA) activator. Especially suitable for intact cells showing preference for site B of type II isozyme. Completely stable against mammalian cPDE types I & III and only extremely slowly hydrolized by cPDE type II. Surpasses the widely used but problematic dibutyryl cAMP or 8-CPT-cAMP in terms of metabolic stability, membrane permeability and potency.

详细说明 (简体中文)

Biochem/physiol Actions
Selective cAMP-dependent protein kinase (PKA) activator. Especially suitable for intact cells showing preference for site B of type II isozyme. Completely stable against mammalian cPDE types I & III and only extremely slowly hydrolized by cPDE type II. Surpasses the widely used but problematic dibutyryl cAMP or 8-CPT-cAMP in terms of metabolic stability, membrane permeability and potency.