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Psammaplin A

产品号 P8749 公司名称 Sigma Aldrich
CAS号 110659-91-1 公司网站 http://www.sigmaaldrich.com
分子式 C22H24Br2N4O6S2 电 话 1-800-521-8956
分子量 664.38716 传 真
纯 度 ≥97% (HPLC) 电子邮件
保 存 Chembase数据库ID: 153164

产品价格信息

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产品别名

标题
Psammaplin A
IUPAC标准名
3-(3-bromo-4-hydroxyphenyl)-N-[2-({2-[3-(3-bromo-4-hydroxyphenyl)-2-(N-hydroxyimino)propanamido]ethyl}disulfanyl)ethyl]-2-(N-hydroxyimino)propanamide
IUPAC传统名
3-(3-bromo-4-hydroxyphenyl)-N-[2-({2-[3-(3-bromo-4-hydroxyphenyl)-2-(N-hydroxyimino)propanamido]ethyl}disulfanyl)ethyl]-2-(N-hydroxyimino)propanamide
别名
Bisprasin, N,N"-(dithiodi-2,1-ethanediyl)bis[3-bromo-4-hydroxy-a-(hydroxyimino)-benzenepropanamide

产品登记号

CAS号 110659-91-1

产品性质

Empirical Formula (Hill Notation) C22H24Br2N4O6S2
纯度 ≥97% (HPLC)
外观 solid
溶解度 DMSO: >10 mg/mL
溶解度 H2O: insoluble
GHS危险品标识 GHS07
GHS警示词 Warning
GHS危险声明 H315-H319-H335
欧盟危险性物质标志 刺激性(Irritant) 刺激性(Irritant) (Xi)
MSDS下载 下载链接
个人保护装置 dust mask type N95 (US), Eyeshields, Gloves
GHS警示性声明 P261-P305 + P351 + P338
危险公开号 36/37/38
安全公开号 26-36/37
保存温度 2-8°C
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
Psammaplin A is an antibiotic, anti-tumor, DNA methyltransferase inhibitor. It is a bromotyrosine-derived, symmetrical conjugate of cystamine, which was first isolated from the Psammaplinaplysilla sponge. Psammaplin A impedes angiogenesis as well as bacterial and tumor cell growth. Psammaplin A inhibits the activities of several key enzymes in prokaryotic and eukaryotic systems including those involved in epigenetic control of gene expression, DNA replication, angiogensis, and microbial detoxification.
详细说明 (简体中文)
Biochem/physiol Actions
Psammaplin A is an antibiotic, anti-tumor, DNA methyltransferase inhibitor. It is a bromotyrosine-derived, symmetrical conjugate of cystamine, which was first isolated from the Psammaplinaplysilla sponge. Psammaplin A impedes angiogenesis as well as bacterial and tumor cell growth. Psammaplin A inhibits the activities of several key enzymes in prokaryotic and eukaryotic systems including those involved in epigenetic control of gene expression, DNA replication, angiogensis, and microbial detoxification.

参考文献