JX401

• 产品号: J4774
• CAS号: 349087-34-9
• 分子式: C21H25NO2S
• 分子量: 355.4937
• 纯 度: >98% (HPLC)

产品别名

• 标题: JX401
• IUPAC标准名: 4-benzyl-1-[2-methoxy-4-(methylsulfanyl)benzoyl]piperidine
• IUPAC传统名: 4-benzyl-1-[2-methoxy-4-(methylsulfanyl)benzoyl]piperidine
• 别名: 1-[2-Methoxy-4-(methylthio)benzoyl]-4-benzylpiperidine

产品登记号

• CAS号: 349087-34-9
• MDL号: MFCD02038777

产品性质

• Empirical Formula (Hill Notation): C21H25NO2S
• 纯度: >98% (HPLC)
• 外观: off-white solid
• 溶解度: DMSO: >5 mg/mL
• GHS警示词: Warning
• GHS危险声明: H410
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• 个人保护装置: Eyeshields, Gloves
• GHS警示性声明: P273-P501
• RID/ADR: UN 3077 9/PG 3
• 危险公开号: 50/53
• 安全公开号: 60-61
• 联合国危险货物等级: 9
• 联合国危险货物编号: 3077
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
JX401 is a potent non-cytotoxic, membrane permeable p38α inhibitor. It is highly specific for p38α with an IC50 value of 32 nM while showing no inhibition for p38γ even at 10 μM. JX401 rescued yeast growth in a dose-dependent manner in p38-expressing cultures and reversibly inhibited myoblast differentiation in mammalian cells in culture.

详细说明 (简体中文)

Biochem/physiol Actions
JX401 is a potent non-cytotoxic, membrane permeable p38α inhibitor. It is highly specific for p38α with an IC50 value of 32 nM while showing no inhibition for p38γ even at 10 μM. JX401 rescued yeast growth in a dose-dependent manner in p38-expressing cultures and reversibly inhibited myoblast differentiation in mammalian cells in culture.