MAZ51

• 产品号: M1695
• CAS号: 163655-37-6
• 分子式: C21H18N2O
• 分子量: 314.38042
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: MAZ51
• IUPAC标准名: 3-{[4-(dimethylamino)naphthalen-1-yl]methylidene}-2,3-dihydro-1H-indol-2-one
• IUPAC传统名: 3-{[4-(dimethylamino)naphthalen-1-yl]methylidene}-1H-indol-2-one
• 别名: 3-(4-Dimethylaminonaphthalen-1-ylmethylene)-1,3-dihydroindol-2-one

产品登记号

• PubChem SID: 24724533
• MDL号: MFCD04036983
• CAS号: 163655-37-6

产品性质

• Empirical Formula (Hill Notation): C21H18N2O
• 纯度: ≥98% (HPLC)
• 外观: orange solid
• 溶解度: DMSO: soluble11 mg/mL
• GHS警示词: Danger
• GHS危险声明: H302-H315-H318-H335-H411
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P273-P280-P305 + P351 + P338
• RID/ADR: UN 3077 9/PG 3
• 危险公开号: 22-37/38-41-51/53
• 安全公开号: 26-39-61
• 保存温度: 2-8°C
• 联合国危险货物等级: 9
• 联合国危险货物编号: 3077
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Cell-permeable VEGFR-3 inhibitor. At low concentration ≥ 5 μM), it specifically blocks VEGF-C- and VEGF-D-induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells. It partially blocks VEGFR-2 phosphorylation only at higher concentrations (50 μM).

详细说明 (简体中文)

Biochem/physiol Actions
Cell-permeable VEGFR-3 inhibitor. At low concentration ≥ 5 μM), it specifically blocks VEGF-C- and VEGF-D-induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells. It partially blocks VEGFR-2 phosphorylation only at higher concentrations (50 μM).