您当前所在的位置:首页 > 产品中心 > 产品信息
Ro 106-9920_分子结构_CAS_62645-28-7)
点击图片或这里关闭

Ro 106-9920

产品号 R9154 公司名称 Sigma Aldrich
CAS号 62645-28-7 公司网站 http://www.sigmaaldrich.com
分子式 C10H7N5OS 电 话 1-800-521-8956
分子量 245.26048 传 真
纯 度 ≥98% (HPLC) 电子邮件
保 存 Chembase数据库ID: 153152

产品价格信息

请登录

产品别名

标题
Ro 106-9920
IUPAC标准名
6-(benzenesulfinyl)-[1,2,3,4]tetrazolo[1,5-b]pyridazine
IUPAC传统名
6-(benzenesulfinyl)-[1,2,3,4]tetrazolo[1,5-b]pyridazine
别名
Tetrazolopyridazine-phenylsulfoxide

产品登记号

MDL号 MFCD06660085
CAS号 62645-28-7
PubChem SID 24724597

产品性质

Empirical Formula (Hill Notation) C10H7N5OS
纯度 ≥98% (HPLC)
外观 solid
溶解度 DMSO: soluble12 mg/mL
MSDS下载 下载链接
保存温度 -20°C

产品详细信息

详细说明 (English)
Biochem/physiol Actions
Exhibits anti-inflammatory activities. Small molecule inhibitor of a novel E3 or IκBα ubiquitin ligase distinct from SCFβTRCP (Skp1-cullin-F box conplex). Prevents IκBα degradation in cell culture (IC50 2.3 ± 0.09 μM). Blocks expression of NF-κB dependent cytokines: TNFα, IL-1β, and IL-6 in both cell culture (IC50 600-700 nM) and in vivo in animal models (NF-KB gene activation requires degradation of IKBα upon phosphorylation by IKK followed by ubiquitination).
Packaging
Light sensitive.
详细说明 (简体中文)
Biochem/physiol Actions
Exhibits anti-inflammatory activities. Small molecule inhibitor of a novel E3 or IκBα ubiquitin ligase distinct from SCFβTRCP (Skp1-cullin-F box conplex). Prevents IκBα degradation in cell culture (IC50 2.3 ± 0.09 μM). Blocks expression of NF-κB dependent cytokines: TNFα, IL-1β, and IL-6 in both cell culture (IC50 600-700 nM) and in vivo in animal models (NF-KB gene activation requires degradation of IKBα upon phosphorylation by IKK followed by ubiquitination).
包装
Light sensitive.

参考文献