您当前所在的位置:首页 > 产品中心 > 产品信息
KRIBB3_分子结构_CAS_129414-88-6)
点击图片或这里关闭

KRIBB3

产品号 K4514 公司名称 Sigma Aldrich
CAS号 129414-88-6 公司网站 http://www.sigmaaldrich.com
分子式 C19H19NO4 电 话 1-800-521-8956
分子量 325.35846 传 真
纯 度 ≥98% (HPLC) 电子邮件
保 存 protect from light Chembase数据库ID: 153151

产品价格信息

请登录

产品别名

标题
KRIBB3
IUPAC标准名
4-ethyl-5-methoxy-2-[4-(4-methoxyphenyl)-1,2-oxazol-5-yl]phenol
IUPAC传统名
4-ethyl-5-methoxy-2-[4-(4-methoxyphenyl)-1,2-oxazol-5-yl]phenol
别名
5-(5-Ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl)isoxazole

产品登记号

CAS号 129414-88-6
MDL号 MFCD00710140
PubChem SID 24896001

产品性质

Empirical Formula (Hill Notation) C19H19NO4
纯度 ≥98% (HPLC)
外观 white to off-white solid
溶解度 DMSO: soluble15 mg/mL
GHS危险品标识 GHS06
GHS警示词 Danger
GHS危险声明 H301-H413
欧盟危险性物质标志 有害性(Harmful) 有害性(Harmful) (Xn)
MSDS下载 下载链接
个人保护装置 dust mask type N95 (US), Eyeshields, Faceshields, Gloves
GHS警示性声明 P301 + P310
RID/ADR UN 2811 6.1/PG 3
危险公开号 22
保存条件 protect from light
保存条件 under inert gas
保存温度 -20°C
联合国危险货物等级 6.1
联合国危险货物编号 2811
联合国危险货物包装类别(PG) 3
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
KRIBB3 is an inhibitior of PKC-dependent phosphorylation of Hsp27 through its direct binding to Hsp27. It has antimigratory and anti-invasive activities in MDA-MB-231 cells. KRIBB3 blocked phorbol 12-myristate 13-acetate-induced phosphorylation of Hsp27 and tumor cell migration. The IC50 is 50 nM, suggesting that KRIBB3 has a high specific affinity for the target protein, Hsp27.
详细说明 (简体中文)
Biochem/physiol Actions
KRIBB3 is an inhibitior of PKC-dependent phosphorylation of Hsp27 through its direct binding to Hsp27. It has antimigratory and anti-invasive activities in MDA-MB-231 cells. KRIBB3 blocked phorbol 12-myristate 13-acetate-induced phosphorylation of Hsp27 and tumor cell migration. The IC50 is 50 nM, suggesting that KRIBB3 has a high specific affinity for the target protein, Hsp27.

参考文献