2-膦酰丁酸三乙酯

• 产品号: 417467
• CAS号: 17145-91-4
• 分子式: C10H21O5P
• 分子量: 252.244501
• 纯 度: 98%

产品别名

• 标题: Triethyl 2-phosphonobutyrate
• IUPAC标准名: ethyl 2-(diethoxyphosphoryl)butanoate
• IUPAC传统名: ethyl 2-(diethoxyphosphoryl)butanoate
• 别名: NSC 22423; α-Diethylphosphonobutanoic acid ethyl ester; Ethyl 2-(diethoxyphosphoryl)butanoate

产品登记号

• MDL号: MFCD00041347
• PubChem SID: 24866152
• CAS号: 17145-91-4

产品性质

• 线性分子式: (C2H5O)2P(O)CH(C2H5)CO2C2H5
• 纯度: 98%
• 沸点: 152-154 °C/14 mmHg(lit.)
• 密度: 1.064 g/mL at 25 °C(lit.)
• 闪点: 113 °C
• 闪点: 235.4 °F
• 折射率: n20/D 1.432(lit.)
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• 安全公开号: 26-36
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Packaging
5, 25 mL in glass bottle
Application
Reactant for preparation of:
• Furospinosulin-1 and analogs as hypoxia-selective antitumor agents1
• Aminoquinolines as beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and potential anti-Alzheimer′s drugs2
• Phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists as nonalcoholic steatohepatitis (NASH)-preventive agents3
• PPAR agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related LXR antagonists4
• Notch-sparing γ-secretase inhibitors derived from PPAR agonist library5
• Plakotenin via Diels-Alder reaction, as a potential anticancer agent, naturally found in Okinawan sponge of the genus Plakortis6
• Quinone/naphthoquinone-substituted propenoic acids as inhibitors of cell growth and redox function of apurinic/apyrimidinic endonuclease 1/redox enhancing factor 1 (Ape1/Ref-1)7
• α-alkenyl cyclic ethers by asymmetric dehydrative cyclization of ω-hydroxy allyl alcohols catalyzed by Ru complexes of axially chiral naphthylpyridinecarboxylates8
• Branched phosphonoethoxyethyl purines as new acyclic nucleoside phosphonates which inhibit Plasmodium falciparum (malarial parasite) hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT)9
• Phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists as candidate drugs for treatment of altered metabolic homeostasis10

详细说明 (简体中文)

包装
5, 25 mL in glass bottle
Application
Reactant for preparation of:
• Furospinosulin-1 and analogs as hypoxia-selective antitumor agents1
• Aminoquinolines as beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and potential anti-Alzheimer′s drugs2
• Phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists as nonalcoholic steatohepatitis (NASH)-preventive agents3
• PPAR agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related LXR antagonists4
• Notch-sparing γ-secretase inhibitors derived from PPAR agonist library5
• Plakotenin via Diels-Alder reaction, as a potential anticancer agent, naturally found in Okinawan sponge of the genus Plakortis6
• Quinone/naphthoquinone-substituted propenoic acids as inhibitors of cell growth and redox function of apurinic/apyrimidinic endonuclease 1/redox enhancing factor 1 (Ape1/Ref-1)7
• α-alkenyl cyclic ethers by asymmetric dehydrative cyclization of ω-hydroxy allyl alcohols catalyzed by Ru complexes of axially chiral naphthylpyridinecarboxylates8
• Branched phosphonoethoxyethyl purines as new acyclic nucleoside phosphonates which inhibit Plasmodium falciparum (malarial parasite) hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT)9
• Phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists as candidate drugs for treatment of altered metabolic homeostasis10