| Item |
Information |
|
Drug Groups
|
approved |
|
Description
|
A cephalosporin antibiotic. [PubChem] |
| Indication |
Used to prevent infection during surgery and to treat many kinds of infections of the blood, bone or joints, respiratory tract, skin, and urinary tract. |
| Pharmacology |
Cefalotin (INN) or cephalothin (USAN) is a semisynthetic first generation cephalosporin having a broad spectrum of antibiotic activity that is administered parenterally. |
| Toxicity |
Rat intravenous LD50 is 4000 mg/kg. |
| Affected Organisms |
| • |
Enteric bacteria and other eubacteria |
|
| Biotransformation |
Metabolized to a less active desacetyl metabolite, although 50-75% of the drug is eliminated unchanged in the urine. |
| Half Life |
30 minutes |
| Protein Binding |
65-80% |
| External Links |
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