三甲基硅烷化重氮甲烷 溶液

• 产品号: 362832
• CAS号: 18107-18-1
• 分子式: C4H10N2Si
• 分子量: 114.2211

产品别名

• 标题: (Trimethylsilyl)diazomethane solution
• IUPAC标准名: (diazomethyl)trimethylsilane
• IUPAC传统名: trimethylsilyldiazomethane
• 别名: (三甲硅烷)重氮甲烷; (Diazomethyl)trimethylsilane

产品登记号

• Beilstein号: 1902903
• MDL号: MFCD00053946
• PubChem SID: 24862335
• CAS号: 18107-18-1

产品性质

• 浓度: 2.0 M in hexanes
• 线性分子式: (CH3)3SiCHN2
• 作用器官: Lungs
• 密度: 0.718 g/mL at 25 °C
• 闪点: -23 °C
• 闪点: -9.4 °F
• GHS警示词: Danger
• GHS危险声明: H225-H304-H315-H330-H336-H350-H361f-H370-H411
• 欧盟危险性物质标志: 易燃性(Flammable) (F)
• 欧盟危险性物质标志: 剧毒(Highly toxic) (T+)
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• 个人保护装置: Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• GHS警示性声明: P201-P210-P260-P273-P281-P284
• RID/ADR: UN 1992 3/PG 2
• 危险公开号: 45-11-26-38-39/26-51/53-62-65-67
• 安全公开号: 53-28-36/37-45-61-62
• 联合国危险货物等级: 3
• 联合国危险货物编号: 1992
• 联合国危险货物包装类别(PG): 2
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Packaging
5, 25, 100, 500 mL in Sure/Seal™
Preparation Note
Preparation of substituted cyclopentenones via [4+1] annulation with vinylketenes.10
Application
Reactant for preparation of:
• Macrolactam analogs of the natural product macrolide (-)-A26771B with improved metabolic stability and antibacterial activity1
• Aigialomycin D analogues as protein kinase inhibitors for cancer treatment2
• Unnatural α-amino acid derivatives containing gem-bisphosphonates via Michael addition reaction3
• Capped 4-methylumbelliferyl hyaluronan disaccharides and tetrasaccharides as potential hyaluronidase substrates4
• Stictamides A-C as matrix metallopeptidase 12 (MMP12) inhibitors with antitumor invasion activity5
• Endothelin converting enzyme (ECE) Inhibitors WS 75624A and WS 75624B via a cross-metathesis approach6
• Ent-kaurene derivatives as anti-inflammatory agents7
• Desmosdumotin C analogs as potent antitumor agents acting via activation of spindle assembly checkpoint8
• Imidazolo[2,1-b]benzothiazole derivatives as potential p53 inhibitors9
Synthetic applications include metathesis and cycloaddition reactions.Regioselective dipolar cycloadditions to give amino acids and azakainoids.

详细说明 (简体中文)

包装
5, 25, 100, 500 mL in Sure/Seal™
Preparation Note
通过与乙烯基乙烯酮类化合物发生 [4+1] 成环反应制备取代环戊烯酮。10
Application
Reactant for preparation of:
• Macrolactam analogs of the natural product macrolide (-)-A26771B with improved metabolic stability and antibacterial activity1
• Aigialomycin D analogues as protein kinase inhibitors for cancer treatment2
• Unnatural α-amino acid derivatives containing gem-bisphosphonates via Michael addition reaction3
• Capped 4-methylumbelliferyl hyaluronan disaccharides and tetrasaccharides as potential hyaluronidase substrates4
• Stictamides A-C as matrix metallopeptidase 12 (MMP12) inhibitors with antitumor invasion activity5
• Endothelin converting enzyme (ECE) Inhibitors WS 75624A and WS 75624B via a cross-metathesis approach6
• Ent-kaurene derivatives as anti-inflammatory agents7
• Desmosdumotin C analogs as potent antitumor agents acting via activation of spindle assembly checkpoint8
• Imidazolo[2,1-b]benzothiazole derivatives as potential p53 inhibitors9
合成用途，包括复分解和环加成反应。 区域选择性偶极环加成反应生成氨基酸和 azakainoid。