Framycetin

• 产品号: DB00452
• CAS号: 119-04-0
• 分子式: C23H46N6O13
• 分子量: 614.64374

产品别名

• 标题: Framycetin
• IUPAC标准名: (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2-{[(2S,3R,4S,5R)-4-{[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy}-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-3-hydroxycyclohexyl]oxy}oxane-3,4-diol
• IUPAC传统名: (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2-{[(2S,3R,4S,5R)-4-{[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy}-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-3-hydroxycyclohexyl]oxy}oxane-3,4-diol
• 商标名: Actiline; Soframycine; Neomycin A; Soframycin Ophthalmic; Soframycin; Actilin; Antibiotique; Enterfram; Fradiomycin B; Framygen; Nebramycin X; Negamicin; Dekamycin V
• 别名: Framycetinum [INN-Latin]; Neomycin B; Streptothricin B

产品登记号

• PubChem SID: 46508892
• PubChem CID: 8378
• CAS号: 119-04-0

产品性质

• 疏水性(logP): -7.8

产品详细信息

详细说明 (English)

• Drug Groups: approved
• Description: A component of neomycin that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed)
• Indication: For the treatment of bacterial blepharitis, bacterial bonjunctivitis, corneal injuries, corneal ulcers and meibomianitis. For the prophylaxis of ocular infections following foreign body removal
• Pharmacology: Framycetin is used for the treatment of bacterial eye infections such as conjunctivitis. Framycetin is an antibiotic. It is not active against fungi, viruses and most kinds of anaerobic bacteria. Framycetin works by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Framycetin is useful primarily in infections involving aerobic bacteria bacteria.
• Affected Organisms: Enteric bacteria and other eubacteria
• External Links: Wikipedia