您当前所在的位置:首页 > 产品中心 > 产品信息
Bendroflumethiazide_分子结构_CAS_73-48-3)
点击图片或这里关闭

Bendroflumethiazide

产品号 DB00436 公司名称 DrugBank
CAS号 73-48-3 公司网站 http://www.ualberta.ca/
分子式 C15H14F3N3O4S2 电 话 (780) 492-3111
分子量 421.4145696 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 319

产品价格信息

请登录

产品别名

标题
Bendroflumethiazide
IUPAC标准名
3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide
IUPAC传统名
bendroflumethiazide
商标名
Plusuril
Rautrax N
Repicin
Benzy-Rodiuran
Bentride
Benuron
Bristuric
Bristuron
Centyl
Intolex
Naigaril
Nikion
Orsile
Aprinox
Benzylrodiuran
Berkozide
Corzide
Flumesil
Livesan
Nateretin
Naturetin
Naturetin-2.5
Naturine
Neo-Naclex
Niagaril
Pluryl
Poliuron
Relan Beta
Salural
Sinesalin
Thiazidico
Urlea
FT 8
Flumersil
Neo-Rontyl
Pluryle
Rauzide
Salures
Sodiuretic
别名
Bendroflumethiazidum [INN-Latin]
Bendrofluazide
Benzylhydroflumethiazide
BHFT
Bendroflumethazide
Bendroflumetiazida [INN-Spanish]
Benzhydroflumethiazide
Benzydroflumethiazide
Bendrofumethiazide

产品登记号

PubChem SID 46508672
PubChem CID 2315
CAS号 73-48-3

产品性质

疏水性(logP) 1.7
溶解度 108 mg/L

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)
Indication For the treatment of high blood pressure and management of edema related to heart failure.
Pharmacology Bendroflumethiazide, a thiazide diuretic, removes excess water from the body by increasing how often you urinate (pass water) and also widens the blood vessels which helps to reduce blood pressure. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Affected Organisms
Humans and other mammals
Absorption Absorbed relatively rapidly after oral administration
Half Life 8.5 hours
Protein Binding 96%
External Links
Wikipedia
Drugs.com

参考文献