胞嘧啶β-D-呋喃阿拉伯糖苷 盐酸盐

• 产品号: 855855
• CAS号: 69-74-9
• 分子式: C9H14ClN3O5
• 分子量: 279.67756
• 纯 度: 98%

产品别名

• 标题: Cytosine β-D-arabinofuranoside hydrochloride
• IUPAC标准名: 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one hydrochloride
• IUPAC传统名: cytarabine hydrochloride
• 别名: Arabinosylcytosine hydrochloride; 阿糖胞嘧啶 盐酸盐; 1-(β-D-呋喃阿拉伯糖苷)-胞嘧啶 盐酸盐; Cytosine Arabinoside Hydrochloride; Arabinocytidine hydrochloride; 1-(β-D-Arabino-furanosyl)-cytosine hydrochloride; Ara-C hydrochloride; Ara-C 盐酸盐; 胞嘧啶阿拉伯糖苷 盐酸盐; 阿拉伯糖胞嘧啶 盐酸盐; 阿糖胞苷 盐酸盐; Cytarabine Hydrochloride

产品登记号

• EC号: 200-713-9
• CAS号: 69-74-9
• MDL号: MFCD00012839

产品性质

• Empirical Formula (Hill Notation): C9H13N3O5 · HCl
• 纯度: 98%
• 熔点: 197-198 °C(lit.)
• 比旋光度: [α]25/D +130°, c = 1 in H2O
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 危险公开号: 36-43-63
• RTECS编号: HA5500000
• 安全公开号: 26-36/37
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Ara-C is phosphorylated to Ara-CTP and is incorporatee into DNA. It inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation, and ultimately induces apoptosis via the PKC signaling pathway.1 Does not inhibit RNA synthesis. Anti-leukemia agent.

详细说明 (简体中文)

Biochem/physiol Actions
Ara-C is phosphorylated to Ara-CTP and is incorporatee into DNA. It inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation, and ultimately induces apoptosis via the PKC signaling pathway.1 Does not inhibit RNA synthesis. Anti-leukemia agent.