3-异丁基-1-甲基黄嘌呤

• 产品号: 858455
• CAS号: 28822-58-4
• 分子式: C10H14N4O2
• 分子量: 222.24376
• 纯 度: 99%

产品别名

• 标题: 3-Isobutyl-1-methylxanthine
• IUPAC标准名: 1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione
• IUPAC传统名: 3 isobutyl 1 methylxanthine
• 别名: 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione; 1-Methyl-3-isobutylxanthine; 3-异丁基-1-甲基-2,6(1H,3H)-嘌呤二酮; 1-甲基-3-异丁基黄嘌呤; 3,7-二氢-1-甲基-3-(2-甲基丙基)-1H-嘌呤-2,6-二酮; 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione; IBMX

产品登记号

• Beilstein号: 247859
• MDL号: MFCD00005584
• CAS号: 28822-58-4
• EC号: 249-259-3

产品性质

• 个人保护装置: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• 危险公开号: 22
• RTECS编号: ZD8500000
• 德国WGK号: 3
• GHS警示词: Warning
• GHS危险声明: H302
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• Empirical Formula (Hill Notation): C10H14N4O2
• 纯度: 99%
• 熔点: 200-201 °C(lit.)

产品详细信息

详细说明 (English)

Application
Potent inhibitor of cyclic nucleotide phosphodiesterase.2,3
Packaging
1 g in glass bottle
100 mg in glass bottle
Biochem/physiol Actions
Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons.1

详细说明 (简体中文)

Application
环核苷酸磷酸二酯酶蛋白抑制剂2,3
包装
1 g in glass bottle
100 mg in glass bottle
Biochem/physiol Actions
Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons.1