您当前所在的位置:首页 > 产品中心 > 产品信息
L-Glutamic Acid_分子结构_CAS_56-86-0)
点击图片或这里关闭

L-Glutamic Acid

产品号 DB00142 公司名称 DrugBank
CAS号 56-86-0 公司网站 http://www.ualberta.ca/
分子式 C5H9NO4 电 话 (780) 492-3111
分子量 147.12926 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 28

产品价格信息

请登录

产品别名

标题
L-Glutamic Acid
IUPAC标准名
(2S)-2-aminopentanedioic acid
IUPAC传统名
L-glutamic acid
商标名
Aciglut
Glusate
Glutacid
Glutamicol
Glutamidex
Glutaminol
Glutaton
别名
(2S)-2-Aminopentanedioic acid
(S)-(+)-Glutamic acid
(S)-2-Aminopentanedioic acid
(S)-Glutamic acid
1-Aminopropane-1,3-dicarboxylic acid
2-Aminoglutaric acid
2-Aminopentanedioic acid
a-Glutamic acid
a-Aminoglutaric acid
L-(+)-Glutamic acid
L-a-Aminoglutaric acid
L-Glutamate
L-Glutaminic acid
Glutaminic acid
Glutamic acid

产品登记号

CAS号 56-86-0
PubChem CID 33032
PubChem SID 46505816

产品性质

疏水性(logP) -3.3
溶解度 8.57 mg/mL at 25 oC [BULL,HB et al. (1978)]

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved; nutraceutical
Description A peptide that is a homopolymer of glutamic acid. [PubChem]
Indication Considered to be nature's "Brain food" by improving mental capacities; helps speed the healing of ulcers; gives a "lift" from fatigue; helps control alcoholism, schizophrenia and the craving for sugar.
Pharmacology In addition to being one of the building blocks in protein synthesis, it is the most widespread neurotransmitter in brain function, as an excitatory neurotransmitter and as a precursor for the synthesis of GABA in GABAergic neurons.
Toxicity Glutamate causes neuronal damage and eventual cell death, particularly when NMDA receptors are activated, High dosages of glutamic acid may include symptoms such as headaches and neurological problems.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic
Absorption Absorbed from the lumen of the small intestine into the enterocytes.Absorption is efficient and occurs by an active transport mechanism.
References
Smith QR: Transport of glutamate and other amino acids at the blood-brain barrier. J Nutr. 2000 Apr;130(4S Suppl):1016S-22S. [Pubmed]
Okumoto S, Looger LL, Micheva KD, Reimer RJ, Smith SJ, Frommer WB: Detection of glutamate release from neurons by genetically encoded surface-displayed FRET nanosensors. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8740-5. Epub 2005 Jun 6. [Pubmed]
Reeds PJ, Burrin DG, Stoll B, Jahoor F: Intestinal glutamate metabolism. J Nutr. 2000 Apr;130(4S Suppl):978S-82S. [Pubmed]
Corrie JE, DeSantis A, Katayama Y, Khodakhah K, Messenger JB, Ogden DC, Trentham DR: Postsynaptic activation at the squid giant synapse by photolytic release of L-glutamate from a 'caged' L-glutamate. J Physiol. 1993 Jun;465:1-8. [Pubmed]
Augustin H, Grosjean Y, Chen K, Sheng Q, Featherstone DE: Nonvesicular release of glutamate by glial xCT transporters suppresses glutamate receptor clustering in vivo. J Neurosci. 2007 Jan 3;27(1):111-23. [Pubmed]
External Links
Wikipedia

参考文献

  • Smith QR: Transport of glutamate and other amino acids at the blood-brain barrier. J Nutr. 2000 Apr;130(4S Suppl):1016S-22S. Pubmed
  • Okumoto S, Looger LL, Micheva KD, Reimer RJ, Smith SJ, Frommer WB: Detection of glutamate release from neurons by genetically encoded surface-displayed FRET nanosensors. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8740-5. Epub 2005 Jun 6. Pubmed
  • Reeds PJ, Burrin DG, Stoll B, Jahoor F: Intestinal glutamate metabolism. J Nutr. 2000 Apr;130(4S Suppl):978S-82S. Pubmed
  • Corrie JE, DeSantis A, Katayama Y, Khodakhah K, Messenger JB, Ogden DC, Trentham DR: Postsynaptic activation at the squid giant synapse by photolytic release of L-glutamate from a 'caged' L-glutamate. J Physiol. 1993 Jun;465:1-8. Pubmed
  • Augustin H, Grosjean Y, Chen K, Sheng Q, Featherstone DE: Nonvesicular release of glutamate by glial xCT transporters suppresses glutamate receptor clustering in vivo. J Neurosci. 2007 Jan 3;27(1):111-23. Pubmed