| Item |
Information |
|
Drug Groups
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approved |
|
Description
|
A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed) |
| Indication |
Sulpiride is indicated for the treatment of schizophrenia. |
| Pharmacology |
Sulpiride is a substituted benzamide derivative and a selective dopamine D2 antagonist with antipsychotic and antidepressant activity. Other benzamide derivatives include metoclopramide, tiapride, and sultopride. |
| Toxicity |
Sulpiride has a relatively low order of acute toxicity. Substantial amounts may cause severe but reversible dystonic crises with torticollis, protrusion of the tongue, and/or trism. In some cases all the classical symptoms typical of severe Parkinson's Disease may be noted; in others, over-sedation/coma may occur. |
| Affected Organisms |
| • |
Humans and other mammals |
|
| Absorption |
Sulpiride is absorbed slowly from the gastrointestinal tract. Its oral bioavailability is only 25 to 35% with marked interindividual differences. |
| Half Life |
6 to 8 hours |
| External Links |
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