Procyclidine

• 产品号: DB00387
• CAS号: 77-37-2
• 分子式: C19H29NO
• 分子量: 287.43966

产品别名

• 标题: Procyclidine
• IUPAC标准名: 1-cyclohexyl-1-phenyl-3-(pyrrolidin-1-yl)propan-1-ol
• IUPAC传统名: procyclidine
• 商标名: Kemadrine; Arpicolin; Procyclid; Osnervan; Elorine; Kemadrin; Lergine; Procyklidin; Prosyklidin; Triciclidina; Triciloid; Tricoloid; Tricyclamol; Vagosin; Metanin; Spamol
• 别名: Procyclidinum [INN-Latin]; Prociclidina [INN-Spanish]

产品登记号

• PubChem SID: 46505553
• CAS号: 77-37-2
• PubChem CID: 4919

产品性质

• 疏水性(logP): 4.2
• 溶解度: Moderately soluble in water, ~ 30 mg/ml

产品详细信息

详细说明 (English)

• Drug Groups: approved
• Description: A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism. [PubChem]
• Indication: For the treatment of all forms of Parkinson's Disease, as well as control of extrapyramidal reactions induced by antipsychotic agents.
• Pharmacology: Procyclidine has an atropine-like action on parasympathetic-innervated peripheral structures including smooth muscle. It's antispasmodic effects are thought to be related to the blockage of central cholinergic receptors M1, M2 and M4. It is used to treat symptomatic Parkinsonism and extrapyramidal dysfunction caused by antipsychotic agents.
• Toxicity: LD₅₀=60 mg/kg (IV in mice)
• Affected Organisms: Humans and other mammals
• Protein Binding: Approximately 100% bound to albumin.
• References: Theodoridis GC, Stark L: Central role of solar information flow in pregenetic evolution. J Theor Biol. 1971 Jun;31(3):377-88. [Pubmed]
• External Links: Wikipedia; Drugs.com

参考文献

• Theodoridis GC, Stark L: Central role of solar information flow in pregenetic evolution. J Theor Biol. 1971 Jun;31(3):377-88. Pubmed