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Buclizine

产品号 DB00354 公司名称 DrugBank
CAS号 82-95-1 公司网站 http://www.ualberta.ca/
分子式 C28H33ClN2 电 话 (780) 492-3111
分子量 433.02802 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 238

产品价格信息

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产品别名

标题
Buclizine
IUPAC标准名
1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)(phenyl)methyl]piperazine
IUPAC传统名
buclizine
商标名
Aphilan R
Histabuticine
Longifene
Hitabutyzyne
Bucladin
Histabutizine
Buclifen
Buclina
Buclodin
Histabutyzine
Histabutyzine Hydrochloride
Posdel
Postafen
Softran
Aphilan-R Base
Bucladin-S
Histabutyzine Dihydrochloride
Vibazine
别名
Buclizine Dihydrochloride
Buclizinum [INN-Latin]
Buclizina [INN-Spanish]
Buclizine Hydrochloride
Histabutyzine Dihydrochloride
Vibazine Hydrochloride

产品登记号

PubChem SID 46507608
PubChem CID 6729
CAS号 82-95-1

产品性质

疏水性(logP) 7.1

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description Buclizine is an antihistamine of the piperazine derivative family. [Wikipedia]
Indication For prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness and vertigo (dizziness caused by other medical problems).
Pharmacology Buclizine is a piperazine-derivative antihistamine used as an antivertigo/antiemetic agent. Buclizine is used in the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness. Additionally, it has been used in the management of vertigo in diseases affecting the vestibular apparatus. Although the mechanism by which buclizine exerts its antiemetic and antivertigo effects has not been fully elucidated, its central anticholinergic properties are partially responsible. The drug depresses labyrinth excitability and vestibular stimulation, and it may affect the medullary chemoreceptor trigger zone. It also possesses anticholinergic, antihistaminic, central nervous system depressant, and local anesthetic effects.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic.
Absorption Rapidly absorbed following oral administration.
External Links
Wikipedia

参考文献