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Aminohippurate

产品号 DB00345 公司名称 DrugBank
CAS号 94-16-6 公司网站 http://www.ualberta.ca/
分子式 C9H10N2O3 电 话 (780) 492-3111
分子量 194.1873 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 229

产品价格信息

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产品别名

标题
Aminohippurate
IUPAC标准名
2-[(4-aminophenyl)formamido]acetic acid
IUPAC传统名
aminohippurate
别名
PAH
Aminohippurate Sodium
Sodium para-Aminohippurate
Aminohippuric acid
Aminohippuric acid Sodium salt
Sodium p-aminohippurate
para-Aminohippurate

产品登记号

CAS号 94-16-6
PubChem CID 2148
PubChem SID 46507106

产品性质

疏水性(logP) -2.2
溶解度 Slightly soluble

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity. [PubChem]
Indication Used to measure effective renal plasma flow (ERPF) and to determine the functional capacity of the tubular excretory mechanism.
Pharmacology Aminohippurate (p-aminohippuric acid, PAH, PAHA) is the glycine amide of p-aminobenzoic acid. It is filtered by the glomeruli and is actively secreted by the proximal tubules. At low plasma concentrations (1.0 to 2.0 mg/100 mL), an average of 90 percent of aminohippurate is cleared by the kidneys from the renal blood stream in a single circulation. It is ideally suited for measurement of ERPF since it has a high clearance, is essentially nontoxic at the plasma concentrations reached with recommended doses, and its analytical determination is relatively simple and accurate. Aminohippurate is also used to measure the functional capacity of the renal tubular secretory mechanism or transport maximum (TmPAH). This is accomplished by elevating the plasma concentration to levels (40-60 mg/100 mL) sufficient to saturate the maximal capacity of the tubular cells to secrete aminohippurate. Inulin clearance is generally measured during TmPAH determinations since glomerular filtration rate (GFR) must be known before calculations of secretory Tm measurements can be done.
Toxicity The intravenous LD50 in female mice is 7.22 g/kg.
Affected Organisms
Humans and other mammals
External Links
Wikipedia
RxList

参考文献