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Metixene

产品号 DB00340 公司名称 DrugBank
CAS号 4969-02-2 公司网站 http://www.ualberta.ca/
分子式 C20H23NS 电 话 (780) 492-3111
分子量 309.46832 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 224

产品价格信息

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产品别名

标题
Metixene
IUPAC标准名
1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine
IUPAC传统名
metixene
商标名
Tremaril hydrochloride
Methixart
Atosil
Contalyl
Tremaril
Tremonil
Trest
别名
Metixeno [INN-Spanish]
Methixene hydrochloride
Metixenum [INN-Latin]
Methixen [German]
Methixene
Metisene [DCIT]
Metixene hydrochloride

产品登记号

PubChem SID 46508970
PubChem CID 4167
CAS号 4969-02-2

产品性质

疏水性(logP) 4.7
溶解度 Soluble as HCl salt

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description Metixene (or methixene) is a anticholinergic used as an anti-parkinson drug. [Wikipedia]
Indication Used for the symptomatic treatment of parkinsonism.
Pharmacology Metixene is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Metixene has been discontinued.
Toxicity Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic. Metabolism occurs via sulfoxydation and N-demethylation.
Absorption Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.
References
[Link]
External Links
Wikipedia

参考文献