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Fluorometholone

产品号 DB00324 公司名称 DrugBank
CAS号 426-13-1 公司网站 http://www.ualberta.ca/
分子式 C22H29FO4 电 话 (780) 492-3111
分子量 376.4616632 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 209

产品价格信息

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产品别名

标题
Fluorometholone
IUPAC标准名
(1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
IUPAC传统名
fluorometholone
商标名
Fluor-op
Trilcin
Delmeson
Flarex
Efflumidex
Cortilet
FML Liquifilm
Flumetholon
FML Forte
Loticort
Oxylone
Fluaton
Ursnon
别名
FML
Fluoromethalone
Fluormetholone
Fluormetholon

产品登记号

CAS号 426-13-1
PubChem SID 46505984
PubChem CID 9878

产品性质

疏水性(logP) 2
溶解度 30 mg/L

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description A glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye. It has also been used topically in the treatment of various skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732)
Indication For the ophthalmic treatment of corticosteroid-responsive inflammation of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe.
Pharmacology Corticosteroids such as fluorometholone inhibit the inflammatory response to a variety of inciting agents and probably delay or slow healing. They inhibit the edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen, and scar formation associated with inflammation.
Toxicity Side effects may include acute anterior uveitis and perforation of the globe. Keratitis, conjunctivitis, corneal ulcers, mydriasis, conjunctival hyperemia, loss of accommodation and ptosis have occasionally been reported following local use of corticosteroids. LD50 = 234 mg/kg (rats)
Affected Organisms
Humans and other mammals
External Links
Wikipedia
RxList
PDRhealth
Drugs.com

参考文献