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Capreomycin

产品号 DB00314 公司名称 DrugBank
CAS号 11003-38-6 公司网站 http://www.ualberta.ca/
分子式 C50H88N28O15 电 话 (780) 492-3111
分子量 1321.41232 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 199

产品价格信息

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产品别名

标题
Capreomycin
IUPAC标准名
(3S)-3,6-diamino-N-{[(2S,5S,8E,11S,15S)-15-amino-11-[(4R)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl]-8-[(carbamoylamino)methylidene]-2-(hydroxymethyl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentaazacyclohexadecan-5-yl]methyl}hexanamide; (3S)-3,6-diamino-N-{[(2S,5S,8E,11S,15S)-15-amino-11-[(4R)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl]-8-[(carbamoylamino)methylidene]-2-methyl-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentaazacyclohexadecan-5-yl]methyl}hexanamide
IUPAC传统名
(3S)-3,6-diamino-N-{[(2S,5S,8E,11S,15S)-15-amino-11-[(4R)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl]-8-[(carbamoylamino)methylidene]-2-(hydroxymethyl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentaazacyclohexadecan-5-yl]methyl}hexanamide; (3S)-3,6-diamino-N-{[(2S,5S,8E,11S,15S)-15-amino-11-[(4R)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl]-8-[(carbamoylamino)methylidene]-2-methyl-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentaazacyclohexadecan-5-yl]methyl}hexanamide
商标名
Ogostal
Caprocin
别名
Capreomycin sulfate
Capastat
Capastat sulfate
Capreomycin sulphate
Capreomycin

产品登记号

PubChem SID 46508514
CAS号 11003-38-6
PubChem CID 3000502

产品性质

疏水性(logP) -9.609
溶解度 Soluble in water as disulfate salt.

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description Cyclic peptide antibiotic similar to viomycin. It is produced by Streptomyces capreolus. [PubChem]
Indication Used in the treatment of tuberculosis in combination with other drugs.
Pharmacology Capreomycin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria, including bacteria responsible for causing tuberculosis (TB).
Toxicity Hypokalemia, hypocalcemia, hypomagnesemia, and an electrolyte disturbance resembling Bartter's syndrome have been reported to occur in patients with capreomycin toxicity. The subcutaneous median lethal dose (LD50) in mice was 514 mg/kg.
Affected Organisms
Enteric bacteria and other eubacteria
Absorption Not absorbed in significant quantities from the gastrointestinal tract and must be administered parenterally.
Elimination When a 1–g dose of capreomycin was given intramuscularly to normal volunteers, 52% was excreted in the urine within 12 hours.
External Links
Wikipedia
Drugs.com

参考文献