| Item |
Information |
|
Drug Groups
|
approved |
|
Description
|
A benzenesulfonamide-phthalimidine that tautomerizes to a benzophenones form. It is considered a thiazide-like diuretic. [PubChem] |
| Indication |
For management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension. |
| Pharmacology |
Chlorthalidone, a monosulfonamyl diuretic, differs form other thiazide diuretics in that a double ring system is incorporated into its structure. Chlorthalidone is used alone or with atenolol in the management of hypertension and edema. |
| Toxicity |
Symptoms of overdose include nausea, weakness, dizziness and disturbances of electrolyte balance. |
| Affected Organisms |
| • |
Humans and other mammals |
|
| Biotransformation |
Liver |
| Absorption |
Absorbed relatively rapidly after oral administration. |
| Half Life |
40 hours |
| Protein Binding |
High (75% [58% to albumin]) |
| Elimination |
The major portion of the drug is excreted unchanged by the kidneys. |
| External Links |
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