Vindesine

• 产品号: DB00309
• CAS号: 59917-39-4
• 分子式: C43H55N5O7
• 分子量: 753.9261

产品别名

• 标题: Vindesine
• IUPAC标准名: methyl (13S,15S,17S)-13-[(1R,9R,10S,11R,12R,19R)-10-carbamoyl-12-ethyl-10,11-dihydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-4-yl]-17-ethyl-17-hydroxy-1,11-diazatetracyclo[13.3.1.0^{4,12}.0^{5,10}]nonadeca-4(12),5,7,9-tetraene-13-carboxylate
• IUPAC传统名: DVA
• 商标名: Eldesine; DAVA; Eldisine
• 别名: Desacetylvinblastine Amide Sulfate; Vindesine Sulfate

产品登记号

• CAS号: 59917-39-4
• PubChem SID: 46504548
• PubChem CID: 40839

产品性质

• 疏水性(logP): 2.9

产品详细信息

详细说明 (English)

• Drug Groups: approved
• Description: Vinblastine derivative with antineoplastic activity against cancer. Major side effects are myelosuppression and neurotoxicity. Vindesine is used extensively in chemotherapy protocols (antineoplastic combined chemotherapy protocols). [PubChem]
• Indication: For the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia and acute panmyelosis
• Pharmacology: Vindesine is indicated for the treatment of acute lymphocytic leukemia of childhood that is resistant to vincristine and non-oat cell lung cancer.Vindesine causes the arrest of cells in metaphase mitosis. It is three times more potent than vincristine and nearly 10 times more potent than vinblastine in causing mitotic arrest in in vitro studies at doses designed to arrest from 10 to 15% of the cells in mitosis. Vindesine and vincristine are approximately equipotent at dose levels that arrest 40 to 50% of the cells in mitosis. Unlike vinblastine, vindesine produces very few postmetaphase cells. Vindesine has demonstrated activity in patients who have relapsed while receiving multiple-agent treatment that included vincristine.
• Affected Organisms: Humans and other mammals
• Biotransformation: Hepatic
• Half Life: 24 hours.
• Protein Binding: 65-75%
• External Links: Wikipedia; RxList