您当前所在的位置:首页 > 产品中心 > 产品信息
(±)Amethopterin hydrate_分子结构_CAS_60388-53-6(anhydrous))
点击图片或这里关闭

(±)Amethopterin hydrate

产品号 A7019 公司名称 Sigma Aldrich
CAS号 60388-53-6(anhydrous) 公司网站 http://www.sigmaaldrich.com
分子式 C20H24N8O6 电 话 1-800-521-8956
分子量 472.45456 传 真
纯 度 ≥95% 电子邮件
保 存 Chembase数据库ID: 134377

产品价格信息

请登录

产品别名

标题
(±)Amethopterin hydrate
IUPAC标准名
2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid hydrate
IUPAC传统名
hydrate methotrexate
别名
MTX
氨甲叶酸
氨甲喋呤
DL-4-Amino-N10-methylpteroylglutamic acid

产品登记号

PubChem SID 24891167
EC号 262-213-7
CAS号 60388-53-6(anhydrous)
MDL号 MFCD00150845

产品性质

纯度 ≥95%
相关基因信息 human ... DHFRP1(573971), FPGS(2356), SLC19A1(6573), TYMS(7298)mouse ... Dhfr(13361)rat ... Dhfr(24312)
外观 yellow to yellow with an orange cast powder
溶解度 H2O: insoluble
溶解度 NaOH: soluble (minimal amount of 0.1 N NaOH to solubilize, then dilute in neutral buffer or saline)
GHS危险品标识 GHS06
GHS危险品标识 GHS08
GHS警示词 Danger
GHS危险声明 H301-H315-H319-H360
欧盟危险性物质标志 有毒(Toxic) 有毒(Toxic) (T)
个人保护装置 Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS警示性声明 P201-P301 + P310-P305 + P351 + P338-P308 + P313
RID/ADR UN 1544 6.1/PG 2
危险公开号 61-25-36/38
RTECS编号 MA1224100
安全公开号 53-26-36/37-45
保存温度 -20°C
联合国危险货物等级 6.1
联合国危险货物编号 1544
联合国危险货物包装类别(PG) 2
德国WGK号 3

产品详细信息

详细说明 (简体中文)
包装
25 mg in poly bottle
500 mg in glass bottle
Reconstitution
Add a minimal amount of 0.1 N NaOH to solubilize, then dilute in neutral buffer or saline. Diluted stock is stable for 1 week refrigerated and for 1 month frozen at -20 °C. References: Cell & Tissue Culture: Laboratory Procedures, Chapter 27, Page 27D:3.2 (A. Doyle, et al., eds, John Wiley) and Cell Biology: A Laboratory Handbook, vol. 2, page 417 (Julio E. Celis, ed., Academic Press).
Application
Amethopterin is a folic acid antagonist and potent anticancer agent. Amethopterin blocks DNA synthesis by preventing the production of tetrahydrofolate cofactors which are required to make thymidine. Amethopterin is actively transported into cells by the folate transporter where it is converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, a dihydrofolate reductase inhibitor.
Biochem/physiol Actions
Amethopterin is a folic acid antagonist and potent anticancer agent. Blocks DNA synthesis by blocking the production of tetrahydrofolate covactors required for the synthesis of thymidine. Amethopterin is actively transported into cells by the folate transporter. In the cell, it is converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase that, in turn, binds to dihydrofolate reductase and inhibits its activity. Amethopterin-polyglutamate is degraded intracellularly by γ-glutamyl hydrolase.

参考文献