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Filipin III from Streptomyces filipinensis_分子结构_CAS_480-49-9)
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Filipin III from Streptomyces filipinensis

产品号 F4767 公司名称 Sigma Aldrich
CAS号 480-49-9 公司网站 http://www.sigmaaldrich.com
分子式 C35H58O11 电 话 1-800-521-8956
分子量 654.82842 传 真
纯 度 ≥85% (HPLC) 电子邮件
保 存 Chembase数据库ID: 134359

产品价格信息

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产品别名

标题
Filipin III from Streptomyces filipinensis
IUPAC标准名
(17Z,19Z,21Z,23Z,25Z)-4,6,8,10,12,14,16,27-octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one
IUPAC传统名
(17Z,19Z,21Z,23Z,25Z)-4,6,8,10,12,14,16,27-octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one

产品登记号

PubChem SID 24894871
CAS号 480-49-9
MDL号 MFCD00466923

产品性质

GHS警示词 Warning
GHS危险声明 H315-H319-H335
欧盟危险性物质标志 刺激性(Irritant) 刺激性(Irritant) (Xi)
个人保护装置 dust mask type N95 (US), Eyeshields, Gloves
GHS警示性声明 P261-P305 + P351 + P338
危险公开号 36/37/38
RTECS编号 RN9800000
安全公开号 26-36
保存温度 -20°C
德国WGK号 3
GHS危险品标识 GHS07
纯度 ≥85% (HPLC)
产品质量级别 PREMIUM

产品详细信息

详细说明 (English)
Biochem/physiol Actions
Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action may be due to altering membrane permeability and associated functions by binding to membrane sterols.4 Filipin inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.5
Other Notes
Filipin III is the major component of 8 isomeric components in filipin.
Application
Filipin has been used in a double staining procedure as a probe for the detection of lipoproteins in polyacrylamide gel1 and immobilized on nitrocellulose membranes.2 It is also widely used to localize and quantitate unesterified cholesterol by virtue of a specific fluorescent complex.3

参考文献