Mizoribine

• 产品号: M3047
• CAS号: 50924-49-7
• 分子式: C9H13N3O6
• 分子量: 259.21602
• 纯 度: ≥98% (TLC)

产品别名

• 标题: Mizoribine
• IUPAC标准名: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxy-1H-imidazole-4-carboxamide
• IUPAC传统名: bredinin
• 别名: N′-(β-D-Ribofuranosyl)-5-hydroxy-imida-zole-4-carboxamide

产品登记号

• MDL号: MFCD00057221
• CAS号: 50924-49-7
• PubChem SID: 24278546

产品性质

• 纯度: ≥98% (TLC)
• GHS警示词: Danger
• GHS危险声明: H315-H319-H335-H360
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 个人保护装置: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS警示性声明: P201-P261-P305 + P351 + P338-P308 + P313
• 危险公开号: 46-60-61-36/37/38
• RTECS编号: NI3980000
• 安全公开号: 53-22-26-36/37/39-45
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Mizoribine is an imidazole nucleoside possessing strong immunosuppressive properties. Selectively blocks T-cell proliferation response to mitogenic and allo-antigenic stimulation. Mizoribine blocks the movement of T cells from G to S phase. In addition, it significantly decreases the number of B cells at the S, G, and M phases. Mizoribine inhibits de novo synthesis of nucleotides by inhibition of inosine monophosphate dehydrogenase. The resulting nucleotide depletion inhibits DNA synthesis.