2-Methoxyestradiol

• 产品号: M6383
• CAS号: 362-07-2
• 分子式: C19H26O3
• 分子量: 302.40794

产品别名

• 标题: 2-Methoxyestradiol
• IUPAC标准名: (1S,10R,11S,14S,15S)-4-methoxy-15-methyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-2,4,6-triene-5,14-diol
• IUPAC传统名: 2-methoxyestradiol
• 别名: 2,3,17β-Trihydroxy-1,3,5(10)-estratriene 2-methyl ether; 2-Hydroxyestradiol 2-methyl ether; 3,17β-Dihydroxy-2-methoxy-1,3,5(10)-estratriene; 1,3,5(10)-Estratriene-2,3,17-triol 2-methyl ether

产品登记号

• CAS号: 362-07-2
• PubChem SID: 24278561
• MDL号: MFCD00010489

产品性质

• 相关基因信息: human ... ESR1(2099), ESR2(2100)
• 外观: white to faint yellow powder
• 溶解度: DMSO: soluble10 mg/mL
• 溶解度: ethanol: soluble10 mg/mL
• 溶解度: H2O: insoluble
• GHS警示词: Danger
• GHS危险声明: H301-H311-H315-H319-H331-H335-H350-H360-H372
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 个人保护装置: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS警示性声明: P201-P261-P280-P301 + P310-P305 + P351 + P338-P311
• RID/ADR: UN 3077 9/PG 3
• 危险公开号: 45-46-60-61-23/24/25-36/37/38-48
• RTECS编号: KG7537500
• 安全公开号: 53-22-26-36/37/39-45
• 联合国危险货物等级: 9
• 联合国危险货物编号: 3077
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
2-Methoxyestradiol (2-ME) is a potent inhibitor of endothelial cell proliferation and angiogenesis. A major estradiol metabolite, it has little affinity for classical estrogen receptors.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. M6383.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.