Deferoxamine mesylate salt

• 产品号: D9533
• CAS号: 138-14-7
• 分子式: C26H52N6O11S
• 分子量: 656.78968
• 纯 度: ≥92.5% (TLC)

产品别名

• 标题: Deferoxamine mesylate salt
• IUPAC标准名: N-(5-aminopentyl)-N-hydroxy-N'-[5-(N-hydroxy-3-{[5-(N-hydroxyacetamido)pentyl]carbamoyl}propanamido)pentyl]butanediamide; methanesulfonic acid
• IUPAC传统名: deferoxamine; methanesulfonic acid
• 别名: Deferoxamine methanesulfonate salt; Desferrioxamine mesylate salt; DFOM

产品登记号

• EC号: 205-314-3
• CAS号: 138-14-7
• PubChem SID: 24894304
• MDL号: MFCD00058605

产品性质

• 纯度: ≥92.5% (TLC)
• 外观: white to off-white powder
• 溶解度: H2O: soluble50 mg/mL
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS编号: UG5310000
• 保存温度: -20°C
• 德国WGK号: 2

产品详细信息

详细说明 (English)

Biochem/physiol Actions
An iron chelator used often in the studies of cell proliferation and apoptosis. Has been shown to have anti-proliferative effects on vascular smooth muscle cells in vitro and in vivo and to arrest cells in the G1 phase. Also reported to induce p53. Induces apoptosis in HL-60 cells by chelating iron. After 48 hrs treatment with 1μM deferoxamine, DNA fragmentation was apparent. Cells treated with 0.1 μM deferoxamine for as little as 24 hours were committed to apoptosis; by 48 hrs nuclear collapse was observed. In some studies it has been shown to have antioxidant properties and to protect cells against H2O2-induced damage.
Deferoxamine is used as a hypoxia-mimetic agent to stabilize Hypoxia Inducible Factor 1 (HIF-1). Deferoxamine stabilizes HIF-1 through the inhibition of Prolyl Hydroxylases (PHDs) which target HIF-1 through degradation. The mechanism of deferoxamine inhibition is likely through the chelation of Fe2+ bound to the active site of PHD which is required for enzymatic activity.