2-Fluoroadenine-9-β-D-arabinofuranoside

• 产品号: F2773
• CAS号: 21679-14-1
• 分子式: C10H12FN5O4
• 分子量: 285.2317832

产品别名

• 标题: 2-Fluoroadenine-9-β-D-arabinofuranoside
• IUPAC标准名: (2R,3S,4S,5R)-2-(6-amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
• IUPAC传统名: fludarabine
• 别名: Fludarabine des-phosphate; F-ara-A; 9-β-D-Arabinofuranosyl-2-fluoroadenine

产品登记号

• MDL号: MFCD00132942
• Beilstein号: 1225932
• CAS号: 21679-14-1
• PubChem SID: 24894830
• EC号: 244-525-5

产品性质

• 相关基因信息: human ... ADORA3(140)rat ... Adora1(29290), Adora2a(25369), Adora3(25370)
• GHS警示词: Warning
• GHS危险声明: H302
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• 危险公开号: 22
• RTECS编号: AU6207000
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Warning
The name fludarabine refers to 9-β-D-arabinofuranosyl-2-fluoroadenine 5′-phosphate, but is sometimes erroneously used for this compound, which lacks the phosphate.
Biochem/physiol Actions
Fludarabine (the 5′-phosphate) is a prodrug that is converted to F-ara-A, which enters cells and accumulates primarily as the 5′-triphosphate. F-ara-A interferes with DNA synthesis and repair and induces apoptosis of cancer cells. F-ara-A also strongly inhibits DNA methylation, particularly methylation of cytosine in CpG dinucleotide sequences.1