Nisin from Lactococcus lactis

• 产品号: N5764
• CAS号: 1414-45-5
• 分子式: C143H230N42O37S7
• 分子量: 3354.0705

产品别名

• 标题: Nisin from Lactococcus lactis
• IUPAC标准名: (2S)-2-{2-[(2S)-2-[(2S)-2-[(2S,3S)-2-[(2S)-2-{[(1R,4S,7R,11R,14S,17R)-7-[(2S)-2-[(2S)-2-[(2S)-2-{[(3R,9S,12S,15S,21S)-21-[(2R)-2-{[(6R,10R,15aS)-10-[(3R,6S,12S,15R)-15-[(2E)-2-[(2S,3S)-2-amino-3-methylpentanamido]but-2-enamido]-12-[(2S)-butan-2-yl]-9-methylidene-6-(2-methylpropyl)-5,8,11,14-tetraoxo-1-thia-4,7,10,13-tetraazacyclohexadecane-3-amido]-9-methyl-1,4,11-trioxo-tetradecahydropyrrolo[2,1-i]1-thia-4,7,10-triazacyclotridecan-6-yl]formamido}-6-aminohexanamido]-15,22-dimethyl-12-(2-methylpropyl)-9-[2-(methylsulfanyl)ethyl]-5,8,11,14,17,20-hexaoxo-1-thia-4,7,10,13,16,19-hexaazacyclodocosan-3-yl]formamido}-3-carbamoylpropanamido]-4-(methylsulfanyl)butanamido]-6-aminohexanamido]-14-(1H-imidazol-5-ylmethyl)-4,8,20-trimethyl-3,6,12,15,21-pentaoxo-9,19-dithia-2,5,13,16,22-pentaazabicyclo[9.9.2]docosan-17-yl]formamido}-3-hydroxypropanamido]-3-methylpentanamido]-3-(1H-imidazol-5-yl)propanamido]-3-methylbutanamido]prop-2-enamido}-6-aminohexanoic acid
• IUPAC传统名: (2S)-2-{2-[(2S)-2-[(2S)-2-[(2S,3S)-2-[(2S)-2-{[(1R,4S,7R,11R,14S,17R)-7-[(2S)-2-[(2S)-2-[(2S)-2-{[(3R,9S,12S,15S,21S)-21-[(2R)-2-{[(6R,10R,15aS)-10-[(3R,6S,12S,15R)-15-[(2E)-2-[(2S,3S)-2-amino-3-methylpentanamido]but-2-enamido]-12-[(2S)-butan-2-yl]-9-methylidene-6-(2-methylpropyl)-5,8,11,14-tetraoxo-1-thia-4,7,10,13-tetraazacyclohexadecane-3-amido]-9-methyl-1,4,11-trioxo-decahydro-2H-pyrrolo[2,1-i]1-thia-4,7,10-triazacyclotridecan-6-yl]formamido}-6-aminohexanamido]-15,22-dimethyl-12-(2-methylpropyl)-9-[2-(methylsulfanyl)ethyl]-5,8,11,14,17,20-hexaoxo-1-thia-4,7,10,13,16,19-hexaazacyclodocosan-3-yl]formamido}-3-carbamoylpropanamido]-4-(methylsulfanyl)butanamido]-6-aminohexanamido]-14-(3H-imidazol-4-ylmethyl)-4,8,20-trimethyl-3,6,12,15,21-pentaoxo-9,19-dithia-2,5,13,16,22-pentaazabicyclo[9.9.2]docosan-17-yl]formamido}-3-hydroxypropanamido]-3-methylpentanamido]-3-(3H-imidazol-4-yl)propanamido]-3-methylbutanamido]prop-2-enamido}-6-aminohexanoic acid

产品登记号

• CAS号: 1414-45-5
• PubChem SID: 24897751
• MDL号: MFCD00131724

产品性质

• 浓度: 2.5% (balance sodium chloride and denatured milk solids)
• 药效: ≥1,000,000 per IU/g
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (简体中文)

Biochem/physiol Actions
Antibiotic with bactericidal action. Binds to the lipid A portion of bacterial lipopolysaccharides. Induces pore formation in the membranes of cortex cells from excised sorghum roots.Mode of Action: Binds to and interferes with the permeability of the cytoplasmic membrane.Antimicrobial spectrum: Gram-negative and Gram-positive bacteria (requires chelator such as EDTA).
Nisin binds to cell wall precursor lipid components (lipid A portion) of bacteria and disrupts cell wall production. Nisin alters the cell membrane which results in the leakage of cytoplasmic components and destruction of the proton motive force1.
包装
Package size based on weight of total solids
Application
Nisin is a polycyclic lantibiotic produced by Lactococcus lactis. It is commonly used as a food preservative. It is used as a selective agent in cell culture for the isolation of gram-negative bacteria, yeast, and moulds. Product N54764 has been used in bioassays to study posttranslational modification of nisin1. Nisin is used to study food preservation.