5′-Deoxy-5′-(methylthio)adenosine

• 产品号: D5011
• CAS号: 2457-80-9
• 分子式: C11H15N5O3S
• 分子量: 297.3335

产品别名

• 标题: 5′-Deoxy-5′-(methylthio)adenosine
• IUPAC标准名: (2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-[(methylsulfanyl)methyl]oxolane-3,4-diol
• IUPAC传统名: methylthioadenosine
• 别名: Methylthioadenosine; MTA

产品登记号

• MDL号: MFCD00010533
• CAS号: 2457-80-9
• Beilstein号: 42420
• PubChem SID: 24893915

产品性质

• 相关基因信息: human ... ADORA2B(136), ADORA3(140)mouse ... Mtap(66902)rat ... Adora1(29290), Adora2a(25369)
• GHS警示词: Warning
• GHS危险声明: H302
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS编号: AU7410000
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
5′-Deoxy-5′-(methylthio)adenosine (Methylthioadenosine) may be used as a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways. Methylthioadenosine is used in studies on bacterial quorum sensing pathways that envolve enzymes such as 5′-Methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN).
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. D5011.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.