Ascomycin from Streptomyces hygroscopicus var. ascomyceticus

• 产品号: A3835
• CAS号: 104987-12-4
• 分子式: C43H69NO12
• 分子量: 792.00746

产品别名

• 标题: Ascomycin from Streptomyces hygroscopicus var. ascomyceticus
• IUPAC标准名: (1R,9S,12S,13R,14S,17R,18Z,21S,23S,24R,25S,27R)-17-ethyl-1,14-dihydroxy-12-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0^4,^9]octacos-18-ene-2,3,10,16-tetrone
• IUPAC传统名: ascomycin

产品登记号

• CAS号: 104987-12-4
• MDL号: MFCD06198665
• PubChem SID: 24890817

产品性质

• 安全公开号: 36/37
• 保存温度: -20°C
• 德国WGK号: 3
• GHS警示词: Warning
• GHS危险声明: H302-H312-H332
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P280
• 危险公开号: 20/21/22
• RTECS编号: KD4185000

产品详细信息

详细说明 (English)

Linkage
An FK506 analog with an ethyl rather than an allyl group at position 21.
Biochem/physiol Actions
Strong immunosuppressant; inhibits allogenic T-lymphocyte proliferation. It binds with high affinity to FKBP and inhibits calcineurin phosphatase in the nM range.