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Bleomycin sulfate from Streptomyces verticillus_分子结构_CAS_9041-93-4)
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Bleomycin sulfate from Streptomyces verticillus

产品号 B5507 公司名称 Sigma Aldrich
CAS号 9041-93-4 公司网站 http://www.sigmaaldrich.com
分子式 C110H168N34O46S7 电 话 1-800-521-8956
分子量 2927.16612 传 真
纯 度 电子邮件
保 存 Chembase数据库ID: 134168

产品价格信息

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产品别名

标题
Bleomycin sulfate from Streptomyces verticillus
IUPAC标准名
bis((3-{[2-(2-{2-[(2R,3R)-2-[(2S,3S,4R)-4-[(2R,3R)-2-({6-amino-2-[(1S)-1-{[(2S)-2-amino-2-carbamoylethyl]amino}-2-carbamoylethyl]-5-methylpyrimidin-4-yl}formamido)-3-{[(2R,3S,4S,5S,6S)-3-{[(2S,3S,4R,5R,6R)-4-(carbamoyloxy)-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3-(1H-imidazol-4-yl)propanamido]-3-hydroxy-2-methylpentanamido]-3-hydroxybutanamido]ethyl}-1,3-thiazol-4-yl)-1,3-thiazol-5-yl]formamido}propyl)dimethylsulfanium) sulfate
IUPAC传统名
bis((3-{[2-(2-{2-[(2R,3R)-2-[(2S,3S,4R)-4-[(2R,3R)-2-({6-amino-2-[(1S)-1-{[(2S)-2-amino-2-carbamoylethyl]amino}-2-carbamoylethyl]-5-methylpyrimidin-4-yl}formamido)-3-{[(2R,3S,4S,5S,6S)-3-{[(2S,3S,4R,5R,6R)-4-(carbamoyloxy)-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3-(1H-imidazol-4-yl)propanamido]-3-hydroxy-2-methylpentanamido]-3-hydroxybutanamido]ethyl}-1,3-thiazol-4-yl)-1,3-thiazol-5-yl]formamido}propyl)dimethylsulfanium) sulfate
别名
Blexane
Blenoxane
Bleo

产品登记号

CAS号 9041-93-4
PubChem SID 24891839
EC号 232-925-2
MDL号 MFCD00070310

产品性质

GHS警示性声明 P281
危险公开号 46-40
RTECS编号 EC5991990
安全公开号 36/37-45
保存温度 2-8°C
德国WGK号 3
GHS危险品标识 GHS08
GHS警示词 Warning
GHS危险声明 H351
欧盟危险性物质标志 有毒(Toxic) 有毒(Toxic) (T)
个人保护装置 Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
痕量阳离子 Cu: ≤0.10%
外观 white crystalline
溶解度 H2O: soluble20 mg/mL

产品详细信息

详细说明 (English)
Application
Recommended for use as a selection agent at 10-100 μg/ml.
Other Notes
A mixture of bleomycin sulfate salts
Biochem/physiol Actions
An antineoplastic antibiotic isolated from Streptomyces verticillus. Binds to DNA, inhibits DNA synthesis and causes DNA scissions at specific base sequences. Needs to bind oxygen and a metal ion such as copper or iron to cleave DNA. Highly selective cleavage of RNA. Inducer and regulator of apoptosis in a variety of cells. Inhibits tumor angiogenesis.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

参考文献