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Phosphoramidon disodium salt

产品号 R7385 公司名称 Sigma Aldrich
CAS号 119942-99-3 公司网站 http://www.sigmaaldrich.com
分子式 C23H32N3Na2O10P 电 话 1-800-521-8956
分子量 587.467581 传 真
纯 度 ≥97% (TLC) 电子邮件
保 存 Chembase数据库ID: 134165

产品价格信息

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产品别名

标题
Phosphoramidon disodium salt
IUPAC标准名
disodium (2S)-3-(1H-indol-3-yl)-2-[(2S)-4-methyl-2-[({[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}phosphinato)amino]pentanamido]propanoate
IUPAC传统名
disodium (2S)-3-(1H-indol-3-yl)-2-[(2S)-4-methyl-2-({[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyphosphinato}amino)pentanamido]propanoate
别名
N-(α-Rhamno-pyranosyl-phos-phono)-L-leucyl-L-tryptophan disodium salt
N-(α-Rhamno-pyranosyl-oxy-hydroxy-phosphinyl)-Leu-Trp disodium salt

产品登记号

MDL号 MFCD00077870
PubChem SID 24278681
CAS号 119942-99-3
Beilstein号 8105669

产品性质

溶解度 H2O: soluble1 mM (Stock solution stable for 1 month at –20° C.)
溶解度 DMSO: soluble
溶解度 methanol: soluble
个人保护装置 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
保存温度 -20°C
德国WGK号 3
纯度 ≥97% (TLC)

产品详细信息

详细说明 (English)
Application
Identification of phosphoramidon as a metallo-endopeptidase inhibitor was used to characterize endothelin converting enzyme as a metallo-endopeptidase.1 Phosphoramidon increases the production of β-amyloid protein, but not amyloid precursor protein, indicating that abnormal amyloid processing in Alzheimer′s disease may be carried out by a metallo-endopeptidase.2
Biochem/physiol Actions
Potent inhibitor of thermolysin and other metallo-endopeptidases. Strongly inhibits mammalian enkephalinase. Does not inhibit trypsin, papain, chymotrypsin or pepsin. Weakly inhibits collagenase. Effective concentration 1-10 μM.
Substrates
Solubility testing at 10 mg/ml in water yields a clear, colorless to light yellow-green solution. The product is also soluble in methanol and DMSO; less soluble in ethanol and ethyl acetate; insoluble in benzene, hexane, and chloroform.Solutions can be stored in aliquots at -20 °C with an expected shelf life of at least one month.

参考文献