Staurosporine from Streptomyces sp.

• 产品号: S4400
• CAS号: 62996-74-1
• 分子式: C28H26N4O3
• 分子量: 466.53104
• 纯 度: ≥95% (HPLC)

产品别名

• 标题: Staurosporine from Streptomyces sp.
• IUPAC标准名: (2S,3R,4R,6S)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^2,^6.0^7,^2^8.0^8,^1^3.0^1^5,^1^9.0^2^0,^2^7.0^2^1,^2^6]nonacosa-8,10,12,14(28),15(19),20(27),21,23,25-nonaen-16-one
• IUPAC传统名: (2S,3R,4R,6S)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^2,^6.0^7,^2^8.0^8,^1^3.0^1^5,^1^9.0^2^0,^2^7.0^2^1,^2^6]nonacosa-8,10,12,14(28),15(19),20(27),21,23,25-nonaen-16-one
• 别名: Antibiotic AM-2282

产品登记号

• CAS号: 62996-74-1
• PubChem SID: 24899603
• Beilstein号: 1060573
• MDL号: MFCD00077402

产品性质

• 纯度: ≥95% (HPLC)
• 产品质量级别: PREMIUM
• 外观: film
• 溶解度: DMSO: soluble
• 溶解度: H2O: insoluble
• 溶解度: ethanol: soluble
• 溶解度: methanol: soluble
• GHS警示词: Danger
• GHS危险声明: H340-H350
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 个人保护装置: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS警示性声明: P201-P308 + P313
• 危险公开号: 45-46
• 安全公开号: 53-45
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells.
Partially reverses MDR, sensitizing cells with MDR phenotype to cytotoxic agents. Inhibits Pgp phosphorylation. However, functional significance of Pgp phosphorylation is ill defined.