Nocodazole

• 产品号: M1404
• CAS号: 31430-18-9
• 分子式: C14H11N3O3S
• 分子量: 301.32044
• 纯 度: ≥99% (TLC)

产品别名

• 标题: Nocodazole
• IUPAC标准名: methyl N-[5-(thiophene-2-carbonyl)-1H-1,3-benzodiazol-2-yl]carbamate
• IUPAC传统名: nocodazol
• 别名: R 17934; Methyl N-(5-thenoyl-2-benzimidazolyl)carbamate; [5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamic acid methyl ester; Methyl [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate; Oncodazole

产品登记号

• CAS号: 31430-18-9
• MDL号: MFCD00005588
• PubChem SID: 24278535
• Beilstein号: 1085978
• EC号: 250-626-5

产品性质

• 纯度: ≥99% (TLC)
• 产品质量级别: PREMIUM
• 相关基因信息: human ... TUBB(203068)
• 外观: white powder
• 熔点: 300 °C (dec.)
• 溶解度: DMSO: soluble10 mg/mL (may require heating)
• 溶解度: H2O: insoluble
• GHS警示词: Warning
• GHS危险声明: H341-H361d
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• GHS警示性声明: P281
• 危险公开号: 63-68
• RTECS编号: DD6521000
• 安全公开号: 36/37
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Antimitotic agent that disrupts microtubules by binding to β?tubulin and preventing formation of one of the two interchain disulfide linkages, thus inhibiting microtubule dynamics, disruption of mitotic spindle function, and fragmentation of the Golgi complex. Arrests the cell cycle at G2/M phase. Prevents phosphorylation of the T cell antigen receptor and inhibits its activity. Stimulates the intrinsic GTPase activity of tubulin. Activates the JNK/SAPK signaling pathway and induces apoptosis in several normal and tumor cell lines.