乳清酸

• 产品号: O2750
• CAS号: 65-86-1
• 分子式: C5H4N2O4
• 分子量: 156.09626
• 纯 度: ≥98% (titration)

产品别名

• 标题: Orotic acid
• IUPAC标准名: 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid
• IUPAC传统名: orotic acid
• 别名: 6-Carboxy-2,4-dihydroxypyrimidine; 6-Carboxyuracil; 2,6-Dihydroxypyrimidine-4-carboxylic acid; Uracil-6-carboxylic acid

产品登记号

• CAS号: 65-86-1
• EC号: 200-619-8
• MDL号: MFCD00006027
• PubChem SID: 24897967
• Beilstein号: 383901

产品性质

• 级别: anhydrous
• 纯度: ≥98% (titration)
• 熔点: ≥300 °C
• GHS警示词: Warning
• GHS危险声明: H302-H315-H319-H335
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 22-36/37/38
• RTECS编号: RM3180000
• 安全公开号: 26
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
Orotic acid (OA) is an intermediate in de novo pyrimidine biosynthesis that may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5′-phospho-α-d-ribose 1′-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5′-monophosphate (OMP). Orotic acid is used as a starting material for the potential commercial bioproduction of uridine 5′-monophosphate (UMP) by microbes such as Corynebacterium ammoniagenes (ATCC 6872) or Saccharomyces cerevisiae. OA may be used to study the AMPK/SREBP-1 dependent cell signaling pathway and transcription regulation mechanisms that induce hepatic lipogenesis.