D-2-脱氧葡萄糖

• 产品号: D3179
• CAS号: 154-17-6
• 分子式: C6H12O5
• 分子量: 164.15648
• 纯 度: ≥98%

产品别名

• 标题: 2-Deoxy-D-glucose
• IUPAC标准名: (3R,4S,5R)-3,4,5,6-tetrahydroxyhexanal
• IUPAC传统名: deoxyglucose
• 别名: 2-脱氧-D-葡糖

产品登记号

• PubChem SID: 24893732
• CAS号: 154-17-6
• MDL号: MFCD00151328
• EC号: 205-823-0
• Beilstein号: 1723331

产品性质

• 痕量阴离子: chloride (Cl-): ≤0.05%
• 痕量阴离子: sulfate (SO42-): ≤0.05%
• 痕量阳离子: Al: ≤0.0005%
• 痕量阳离子: Ca: ≤0.003%
• 痕量阳离子: Cu: ≤0.0005%
• 痕量阳离子: Fe: ≤0.0005%
• 痕量阳离子: K: ≤0.005%
• 痕量阳离子: Mg: ≤0.0005%
• 痕量阳离子: NH4+: ≤0.05%
• 痕量阳离子: Na: ≤0.005%
• 痕量阳离子: Pb: ≤0.001%
• 痕量阳离子: Zn: ≤0.0005%
• 燃烧残渣: <0.1%
• 杂质: ≤0.001% Phosphorus (P)
• 杂质: <0.1% Insoluble matter
• 纯度: ≥98%
• 熔点: 146-147 °C(lit.)
• 溶解度: H2O: soluble1 M at 20 °C, clear, colorless
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.
Biochem/physiol Actions
2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.1