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Pyrazinecarboxamide_分子结构_CAS_98-96-4)
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Pyrazinecarboxamide

产品号 P7136 公司名称 Sigma Aldrich
CAS号 98-96-4 公司网站 http://www.sigmaaldrich.com
分子式 C5H5N3O 电 话 1-800-521-8956
分子量 123.1127 传 真
纯 度 电子邮件
保 存 Chembase数据库ID: 223

产品价格信息

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产品别名

标题
Pyrazinecarboxamide
IUPAC标准名
pyrazine-2-carboxamide
IUPAC传统名
pyrazinamide
别名
Pyrazinoic acid amide
Pyrazinamide

产品登记号

EC号 202-717-6
PubChem SID 24278648
CAS号 98-96-4
MDL号 MFCD00006132
Beilstein号 112306

产品性质

熔点 189-191 °C(lit.)
个人保护装置 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECS编号 UQ2275000
德国WGK号 3

产品详细信息

详细说明 (简体中文)
包装
10, 25, 100 g in poly bottle
Application
Pyrazinamide is used therapeutically as an antitubercular agent. Pyrazinamide is used to form polymeric copper complexes, create pyrazine carboxamide scaffolds useful as FXs inhibitors, and as a component of mycobacteria identification kits. It is used to study liver toxicity prevention 1 and mechanisms of resistance 2.
Pyrazinamide is used to form polymeric copper complexes, create pyrazine carboxamide scaffolds useful as FXs inhibitors, and as a component of mycobacteria identification kits.
Biochem/physiol Actions
The active moiety of pyrazinamide is pyrazinoic acid (POA). POA is thought to disrupt membrane energetics and inhibit membrane transport function at acid pH in Mycobacterium tuberculosis. Iron enhances the antituberculous activity of pyrazinamide 3. Pyrazinamide and its analogs have been shown to inhibit the activity of purified FAS I.

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