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Penciclovir

产品号 DB00299 公司名称 DrugBank
CAS号 39809-25-1 公司网站 http://www.ualberta.ca/
分子式 C10H15N5O3 电 话 (780) 492-3111
分子量 253.2578 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 184

产品价格信息

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产品别名

标题
Penciclovir
IUPAC标准名
2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6,9-dihydro-3H-purin-6-one
IUPAC传统名
penciclovir
商标名
Denavir
别名
PE2
Penciclovirum [INN-Latin]

产品登记号

PubChem CID 4725
PubChem SID 46506498
CAS号 39809-25-1

产品性质

疏水性(logP) -1.1
溶解度 1.7mg/ml

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description Penciclovir is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections. It is a nucleoside analogue which exhibits low toxicity and good selectivity. [Wikipedia]
Indication Used to treat recurrent cold sores on the lips and face from various herpesvirus invections.
Pharmacology Penciclovir is the active metabolite of the oral product famciclovir. The more favorable results observed with topical penciclovir versus topical acyclovir for the treatment of herpes labialis may be due to the longer intracellular half-life of penciclovir in HSV-infected cells. The activated drug inhibits the viral DNA polymerase. This impairs the ability of the virus to replicate within the cell.
Toxicity Symptoms of overdose include headache, abdominal pain, increased serum lipase, nausea, dyspepsia, dizziness, and hyperbilirubinemia.
Affected Organisms
Herpes simplex virus
Biotransformation Hepatic
Absorption Measurable penciclovir concentrations were not detected in plasma or urine of healthy male volunteers (n= 12) following single or repeat application of the 1% cream at a dose of 180 mg penciclovir daily.
Half Life 2 hours
Protein Binding Less than 20%.
External Links
Wikipedia
RxList
Drugs.com

参考文献