Z-Leu-Leu-Leu-al

• 产品号: C2211
• CAS号: 133407-82-6
• 分子式: C26H41N3O5
• 分子量: 475.62084
• 纯 度: ≥90% (HPLC)

产品别名

• 标题: Z-Leu-Leu-Leu-al
• IUPAC标准名: benzyl N-[(1S)-3-methyl-1-{[(1S)-3-methyl-1-{[(2S)-4-methyl-1-oxopentan-2-yl]carbamoyl}butyl]carbamoyl}butyl]carbamate
• IUPAC传统名: benzyl N-[(1S)-3-methyl-1-{[(1S)-3-methyl-1-{[(2S)-4-methyl-1-oxopentan-2-yl]carbamoyl}butyl]carbamoyl}butyl]carbamate
• 别名: MG132

产品登记号

• CAS号: 133407-82-6
• MDL号: MFCD00674886
• PubChem SID: 24892475

产品性质

• 纯度: ≥90% (HPLC)
• 品质说明: proteasome inhibition tested
• 相关基因信息: human ... CTSB(1508), NFKB1(4790), PSMA1(5682)
• 外观: powder
• 溶解度: DMSO: soluble
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Amino Acid Sequence
Z-Leu-Leu-Leu-al
Frequently Asked Questions
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Biochem/physiol Actions
Potent, membrane-permeable proteasome inhibitor. Induces neurite outgrowth in PC12 cells at 10 μM. Blocks cleavage of poly(ADP-ribose) polymerase and apoptosis in thymocytes. Proteasome inhibition induces accumulation of heat shock protein mRNA, activation of heat-shock proteins, and enhanced thermotolerance in various cell types: however, it also activates JNK-1, which initiates apoptosis in response to cell stress.