他莫昔芬

• 产品号: T5648
• CAS号: 10540-29-1
• 分子式: C26H29NO
• 分子量: 371.51456
• 纯 度: ≥99%

产品别名

• 标题: Tamoxifen
• IUPAC标准名: (2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethyl)dimethylamine
• IUPAC传统名: tamoxifen
• 别名: (Z)-2-[4-(1,2-二苯基-1-丁烯)苯氧基]-N,N-二甲基乙胺; (Z)-1-(对二甲基氨基乙氧基苯基)-1,2-二苯基-1-丁烯

产品登记号

• PubChem SID: 24900307
• MDL号: MFCD00010454
• EC号: 234-118-0
• CAS号: 10540-29-1

产品性质

• 纯度: ≥99%
• 相关基因信息: human ... CYP1A2(1544), EBP(10682), ESR1(2099), ESR2(2100), ESRRA(2101)rat ... Ar(24208), Esr1(24890)
• 熔点: 97-98 °C(lit.)
• GHS警示词: Danger
• GHS危险声明: H350-H360-H362
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 个人保护装置: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS警示性声明: P201-P263-P308 + P313
• 危险公开号: 45-60-61-64
• RTECS编号: KR5919600
• 安全公开号: 53-45
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (简体中文)

Frequently Asked Questions
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General description
Tamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells.
Biochem/physiol Actions
蛋白激酶 C 抑制剂。诱发人类恶性神经胶质瘤细胞系的细胞凋亡。他莫昔芬及其代谢产物 4-羟基他莫昔芬是选择性雌激素反应调节剂 (SERM)，在乳腺中用作雌激素拮抗剂。阻止乳腺肿瘤细胞中雌二醇刺激的 VEGF 的产生。