呋喃唑酮

• 产品号: F9505
• CAS号: 67-45-8
• 分子式: C8H7N3O5
• 分子量: 225.15828

产品别名

• 标题: Furazolidone
• IUPAC标准名: 3-[(E)-[(5-nitrofuran-2-yl)methylidene]amino]-1,3-oxazolidin-2-one
• IUPAC传统名: furazolum
• 别名: 3-(5-硝基呋喃甲叉氨基)-2-噁唑烷酮

产品登记号

• MDL号: MFCD00010550
• EC号: 200-653-3
• PubChem SID: 24894997
• CAS号: 67-45-8
• Beilstein号: 8317414

产品性质

• GHS警示词: Warning
• GHS危险声明: H361
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS警示性声明: P281
• 危险公开号: 62
• RTECS编号: RQ3675000
• 安全公开号: 36
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone binds bacterial DNA, which leads to the gradual inhibition of monoamine oxidase. It is used to treat anorexia and antagonism of thiamin utilization in poultry1. Furazolidone increases thapsigargin-sensitive Ca2+-ATPase in chick cardiac myocytes2.
Biochem/physiol Actions
Furazolidone and its generated free radicals, may bind to DNA and induce cross-links. Bacterial DNA is particularly susceptible to this drug, which results in high levels of mutations (transitions and transversions) in the bacterial chromosome. Its mechanism of action minimizes the development of resistant organisms. Furazolidone is a monoamine oxidase (MAO) inhibitor. It increases thapsigargin-sensitive Ca2+-ATPase in chick cardiac myocytes2.
Furazolidone is a monoamine oxidase (MAO) inhibitor and is used as a DNA interstrand cross-linking agent.