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磺胺噻唑 钠盐_分子结构_CAS_144-74-1)
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磺胺噻唑 钠盐

产品号 S0127 公司名称 Sigma Aldrich
CAS号 144-74-1 公司网站 http://www.sigmaaldrich.com
分子式 C9H8N3NaO2S2 电 话 1-800-521-8956
分子量 277.29849 传 真
纯 度 ≥99% 电子邮件
保 存 Chembase数据库ID: 102904

产品价格信息

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产品别名

标题
Sulfathiazole sodium salt
IUPAC标准名
4-amino-N-sodio-N-(1,3-thiazol-2-yl)benzene-1-sulfonamide
IUPAC传统名
4-amino-N-sodio-N-(1,3-thiazol-2-yl)benzenesulfonamide
别名
4-Amino-N-(2-thiazolyl)benzenesulfonamide sodium salt

产品登记号

CAS号 144-74-1
MDL号 MFCD00072133
EC号 205-638-5
PubChem SID 24899426
Beilstein号 3802297

产品性质

纯度 ≥99%
GHS危险品标识 GHS07
GHS警示词 Warning
GHS危险声明 H315-H319-H335
欧盟危险性物质标志 刺激性(Irritant) 刺激性(Irritant) (Xi)
个人保护装置 dust mask type N95 (US), Eyeshields, Gloves
GHS警示性声明 P261-P305 + P351 + P338
危险公开号 36/37/38
RTECS编号 WP2450000
安全公开号 26-36
德国WGK号 2

产品详细信息

详细说明 (English)
Application
Sulfathiazole is a short-acting sulfa drug. It was a common oral and topical antibiotic until less toxic alternatives were discovered. It is no longer used in humans1. Sulfathiazole is added to the diet of laboratory animals to inhibit folate formation by gut bacteria. This ensures that the animal’s only source of available folate is from their diet2.
Biochem/physiol Actions
Sulfathiazole is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfathiazole is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid1. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

参考文献