15(S)-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid

• 产品号: H1142
• CAS号: 54845-95-3
• 分子式: C20H32O3
• 分子量: 320.46628
• 纯 度: ≥97.0% (HPLC)

产品别名

• 标题: 15(S)-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid
• IUPAC标准名: (5Z,8Z,11Z,13E,15S)-15-hydroxyicosa-5,8,11,13-tetraenoic acid
• IUPAC传统名: 15 hete
• 别名: (15S,5Z,8Z,11Z,13E)-15-Hydroxyeicosatetraenoic acid; (S)-15-HETE; 15(S)-HETE

产品登记号

• PubChem SID: 24895431
• MDL号: MFCD00063590
• Beilstein号: 2470466
• CAS号: 54845-95-3

产品性质

• 浓度: ~150 μg/mL in ethanol
• 纯度: ≥97.0% (HPLC)
• 运输包装: dry ice
• 闪点: 14 °C
• 闪点: 57.2 °F
• GHS警示词: Danger
• GHS危险声明: H225-H315-H319-H335
• 欧盟危险性物质标志: 易燃性(Flammable) (F)
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• GHS警示性声明: P210-P261-P305 + P351 + P338
• RID/ADR: UN 1170 3/PG 2
• 危险公开号: 11-36/37/38
• 安全公开号: 7-16-26-36
• 保存温度: -20°C
• 联合国危险货物等级: 3
• 联合国危险货物编号: 1170
• 联合国危险货物包装类别(PG): 2
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Metabolite of arachidonic acid via the 15-lipoxygenase pathway that may be involved in pulmonary anti-inflammatory responses through the inhibition of 5-lipoxygenase. 15(S)-HETE suppresses the incorporation of thymidine and biosynthesis of prostaglandin E2 in tumor cell cultures. Treatment of colon cancer cells with 15(S)-HETE inhibited cell proliferation and induced apoptosis, which was preceded by an increase in TGF-beta-inducible early gene (TIEG) and a decrease in Bcl-2.