Prostaglandin I2 sodium salt

• 产品号: P6188
• CAS号: 61849-14-7
• 分子式: C20H31NaO5
• 分子量: 374.44691
• 纯 度: ≥96% (HPLC)

产品别名

• 标题: Prostaglandin I2 sodium salt
• IUPAC标准名: sodium 5-[(3E,3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-hexahydro-2H-cyclopenta[b]furan-3-ylidene]pentanoate
• IUPAC传统名: sodium 5-[(3E,3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-hexahydrocyclopenta[b]furan-3-ylidene]pentanoate
• 别名: PGI2-Na; Epoprostenol 钠; (5Z,9α,11α,13E,15S)-6,9-Epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid sodium salt; Prostacyclin sodium salt

产品登记号

• PubChem SID: 24898653
• MDL号: MFCD00135629
• EC号: 263-273-7
• CAS号: 61849-14-7
• Beilstein号: 6472195

产品性质

• 生物来源: synthetic
• 纯度: ≥96% (HPLC)
• 外观: white to off-white powder
• 溶解度: H2O: soluble1 mg/mL (Hydrolyzes to 6-ketoprostaglandin F1α in aqueous solution.)
• 溶解度: ethanol: soluble50 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302-H312-H332
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P280
• 危险公开号: 20/21/22
• 安全公开号: 22-26-36
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Prostacyclin is a short-lived product of the cyclooxygenase pathway in vascular endothelial cells. It is a potent inhibitor of platelet aggregation by antagonizing thromboxane A2 and stimulating platelet adenylyl cyclase.1 Nitric oxide is also produced in vascular endothelium where it inhibits platelet aggregation, regulates inducible cyclooxygenase production, and may work synergistically with prostacyclin to attenuate the thrombotic process. Prostacyclin is vasoprotective, protecting arterial walls from injury-induced lesions and cytoprotective in the liver and gastrointestinal tract.
Prostacyclin therapy improves hemodynamics in pulmonary arterial hypertension.