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Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate_分子结构_CAS_25612-73-1(freeacid))
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Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate

产品号 A2647 公司名称 Sigma Aldrich
CAS号 25612-73-1(freeacid) 公司网站 http://www.sigmaaldrich.com
分子式 C10H15Li4N6O13P3 电 话 1-800-521-8956
分子量 547.943783 传 真
纯 度 ≥93% (HPLC) 电子邮件
保 存 Chembase数据库ID: 133732

产品价格信息

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产品别名

标题
Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate
IUPAC标准名
tetralithium(1+) ion hydrate {[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxy)phosphinato]amino}phosphonate
IUPAC传统名
tetralithium(1+) ion hydrate ({[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxyphosphinato)aminophosphonate
别名
β,γ-Imidoadenosine 5′-triphosphate lithium salt hydrate
Adenylyl imidodiphosphate lithium salt hydrate
ATP[β,γ-NH]
AMP-PNP
App(NH)p

产品登记号

CAS号 25612-73-1(freeacid)
Beilstein号 6047109
PubChem SID 24890685

产品性质

纯度 ≥93% (HPLC)
运输包装 dry ice
外观 white powder
溶解度 H2O: soluble50 mg/mL
个人保护装置 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
保存温度 -20°C
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
A non-hydrolyzable ATP analog. AMP-PNP competitively inhibits ATP-dependent enzyme systems, such as glutamine synthetase. It inhibits a number of enzymes which require the hydrolysis of ATP such as DNA topoisomerase II, SV40 large T-antigen helicase and a number of kinases. Blocks ATP-sensitive calcium-dependent potassium channels.
Caution
AMP-PNP is very unstable in acidic conditions; rapidly hydrolyzes to the phosphoramidate and inorganic phosphate.
Reconstitution
A 10 mg/mL stock solution may be made, aliquoted and stored at -70 °C for up to 3 months.
Application
Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate has been used in a study to research the effects of monovalent cations Li+, Na+, K+, NH4+, Rb+ and Cs+ on the solid and solution structures of the nucleic acid components. Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate has also been used in a study to determine that antidepressants inhibit interferon-γ-induced microglial production of IL-6 and nitric oxide.

参考文献