苯并[a]芘

• 产品号: B1760
• CAS号: 50-32-8
• 分子式: C20H12
• 分子量: 252.30928
• 纯 度: ≥96% (HPLC)

产品别名

• 标题: Benzo[a]pyrene
• IUPAC标准名: pentacyclo[10.6.2.0^2,^7.0^9,^1^9.0^1^6,^2^0]icosa-1(18),2(7),3,5,8,10,12,14,16,19-decaene
• IUPAC传统名: pentacyclo[10.6.2.0^2,^7.0^9,^1^9.0^1^6,^2^0]icosa-1(18),2(7),3,5,8,10,12,14,16,19-decaene
• 别名: 苯并[det]屈; 苯并芘; 3,4-苯并芘

产品登记号

• MDL号: MFCD00003602
• PubChem SID: 24891610
• CAS号: 50-32-8
• Beilstein号: 1911333
• EC号: 200-028-5

产品性质

• 纯度: ≥96% (HPLC)
• 沸点: 495 °C(lit.)
• 熔点: 177-180 °C(lit.)
• GHS警示词: Danger
• GHS危险声明: H317-H340-H350-H360FD-H410
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• GHS警示性声明: P201-P273-P280-P308 + P313-P501
• RID/ADR: UN 3077 9/PG 3
• 危险公开号: 45-46-60-61-43-50/53
• RTECS编号: DJ3675000
• 安全公开号: 53-45-60-61
• 联合国危险货物等级: 9
• 联合国危险货物编号: 3077
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
A polycyclic aromatic hydrocarbon (PAH), environmental pollutant and carcinogen. Used as a chemical carcinogen in experimental models of cancer. Carcinogenesis depends on it′s oxidation by CYP1A1 to benzo[a]pyrenediolepoxide, that forms depurinating adducts with DNA that dissociate to form abasic lesions. Benzo[a]pyrene is a ligand for the arylhydrocarbon receptor (AhR), and some of its biological effects, including the induction of CYP1A1, appear to be mediated via activation of the AhR.