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金精三羧酸 铵盐_分子结构_CAS_569-58-4)
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金精三羧酸 铵盐

产品号 A0885 公司名称 Sigma Aldrich
CAS号 569-58-4 公司网站 http://www.sigmaaldrich.com
分子式 C22H23N3O9 电 话 1-800-521-8956
分子量 473.43272 传 真
纯 度 电子邮件
保 存 Chembase数据库ID: 81618

产品价格信息

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产品别名

标题
Aurintricarboxylic acid ammonium salt
IUPAC标准名
5-[(3-carboxy-4-hydroxyphenyl)(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-2-hydroxybenzoic acid triamine
IUPAC传统名
aurintricarboxylic acid triamine
别名
ATA
Aluminon
Ammonium aurintricarboxylate

产品登记号

Beilstein号 3900820
CAS号 569-58-4
PubChem SID 24890465
Color Index Number 43810
EC号 209-319-1
MDL号 MFCD00040925

产品性质

外观 powder
熔点 220-225 °C (dec.)(lit.)
GHS危险品标识 GHS07
GHS警示词 Warning
GHS危险声明 H315-H319
欧盟危险性物质标志 刺激性(Irritant) 刺激性(Irritant) (Xi)
个人保护装置 dust mask type N95 (US), Eyeshields, Gloves
GHS警示性声明 P305 + P351 + P338
危险公开号 36/38
RTECS编号 GU4800000
安全公开号 26-36
德国WGK号 2

产品详细信息

详细说明 (简体中文)
Other Notes
May contain a substantial amount of polymeric material.
包装
25 g in glass bottle
Biochem/physiol Actions
Aurintricarboxylic acid readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions1. It is a potent inhibitor of ribonuclease1 and topoisomerase II2 by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells3, ErbB4 in neuroblastoma cells4, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells5. Aurintricarboxylic acid inhibits apoptosis in many cell types. Its neuroprotective effect, perhaps due to its ability to prevent down-regulation of Ca2+ impermeable GluR2 receptors6 or to its ability to inhibit calpain, a Ca2+-activated protease that is activated during apoptosis7.

参考文献