Acycloguanosine

• 产品号: A4669
• CAS号: 59277-89-3
• 分子式: C8H11N5O3
• 分子量: 225.20464
• 纯 度: ≥99% (HPLC)

产品别名

• 标题: Acycloguanosine
• IUPAC标准名: 2-amino-9-[(2-hydroxyethoxy)methyl]-6,9-dihydro-1H-purin-6-one
• IUPAC传统名: zovir
• 别名: 9-[(2-Hydroxyethoxy)methyl]guanine; Acyclovir

产品登记号

• PubChem SID: 24278078
• CAS号: 59277-89-3
• MDL号: MFCD00057880
• EC号: 261-685-1

产品性质

• 纯度: ≥99% (HPLC)
• 相关基因信息: human ... HV1S(3365), NP(4860)
• 紫外吸收波长: ε1mM/256 nm 11.8
• 外观: white powder
• 溶解度: H2O: soluble0.7 mg/mL
• 溶解度: 1 M HCl: soluble50 mg/mL
• 溶解度: DMSO: soluble7 mg/mL
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS编号: UP0791400
• 德国WGK号: 2

产品详细信息

详细说明 (English)

Application
Acycloguanosine has been used to study herpes simplex virus latency and reactivation, as well as HIV retrovirus reproduction. Acycloguanosine inhibits replication of cytomegalovirus by a mechanism that is independent of its phosphorylation by viral or cellular thymidine kinase.
Biochem/physiol Actions
Antiviral agent. Phosphorylation by herpes simplex virus thymidine kinase (HSV-TK) leads to the formation of acycloguanosine triphosphate that competitively inhibits the viral DNA polymerase.
Antiviral agent. Phosphorylation by herpes simplex virus thymidine kinase (HSV-TK) leads to the formation of acycloguanosine triphosphate that competitively inhibits the viral DNA polymerase. Acycloguanosine can be used to induce apoptosis in cells transfected with HSV-TK. Inhibits replication of cytomegalovirus by a mechanism that is independent of its phosphorylation by viral or cellular thymidine kinase.